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1526-73-4

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1526-73-4 Usage

General Description

2-Chloro-3-hydroxy-1,4-naphthoquinone, also known as Clotrimazole, is an organic compound with a chemical formula C10H5ClO3. It is a derivative of naphthoquinone and is commonly used as an antifungal medication. Clotrimazole works by inhibiting the growth of fungus on the skin and nails, making it effective in treating various fungal infections. It can be found in various forms such as cream, lotion, and powder, and is often used to treat conditions such as athlete's foot, ringworm, and vaginal yeast infections. This chemical can also be used in the synthesis of other organic compounds and as a reagent in chemical reactions.

Check Digit Verification of cas no

The CAS Registry Mumber 1526-73-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,5,2 and 6 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1526-73:
(6*1)+(5*5)+(4*2)+(3*6)+(2*7)+(1*3)=74
74 % 10 = 4
So 1526-73-4 is a valid CAS Registry Number.
InChI:InChI=1/C10H5ClO3/c11-7-8(12)5-3-1-2-4-6(5)9(13)10(7)14/h1-4,12H

1526-73-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-chloro-4-hydroxynaphthalene-1,2-dione

1.2 Other means of identification

Product number -
Other names 3-chloro-2-hydroxy-naphthalene-1,4-dione

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1526-73-4 SDS

1526-73-4Relevant articles and documents

SYNTHESIS AND BIOLOGICAL ACTIVITY OF 4-SUBSTITUTED 1,2-NAPHTHOQUINONES, 1,2-NAPHTHALENEDIOLS, AND THEIR DERIVATIVES

Grinev, A. N.,Arsenichev, I. K.,Nikolaeva, I. S.,Golovanova, L. A.,Pushkina, T. V.,et al.

, p. 411 - 417 (1985)

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Regiocontrolled synthesis and HIV inhibitory activity of unsymmetrical binaphthoquinone and trimeric naphthoquinone derivatives of conocurvone

Stagliano, Kenneth W.,Emadi, Ashkan,Lu, Zhenhai,Malinakova, Helena C.,Twenter, Barry,Yu, Min,Holland, Louis E.,Rom, Amanda M.,Harwood, John S.,Amin, Ronak,Johnson, Allison A.,Pommier, Yves

, p. 5651 - 5665 (2006)

Unsymmetrical biquinone and trimeric quinone derivatives were synthesized using halotriflate-biselectrophilic naphthoquinones through stepwise regioselective quinone substitution chemistry and evaluated for their ability to inhibit the cytopathogenic effects of HIV-1 using an MTT colorimetric assay. Compounds were also screened for their ability to inhibit the activity of HIV-1 integrase in vitro. Pyranylated trimeric quinones and biquinones exhibited both antiviral activity and integrase inhibitory activity. Conocurvone 1 and trimeric quinone 21 were the most potent HIV integrase inhibitors in the series. All of the biquinones showed HIV inhibitory activity. Simple methoxy substituted biquinones did not inhibit HIV-1 integrase.

Tridentate 3-Substituted Naphthoquinone Ruthenium Arene Complexes: Synthesis, Characterization, Aqueous Behavior, and Theoretical and Biological Studies

Geisler, Heiko,Westermayr, Julia,Cseh, Klaudia,Wenisch, Dominik,Fuchs, Valentin,Harringer, Sophia,Plutzar, Sarah,Gajic, Natalie,Hejl, Michaela,Jakupec, Michael A.,Marquetand, Philipp,Kandioller, Wolfgang

, p. 9805 - 9819 (2021/06/30)

A series of nine RuII arene complexes bearing tridentate naphthoquinone-based N,O,O-ligands was synthesized and characterized. Aqueous stability and their hydrolysis mechanism were investigated via UV/vis photometry, HPLC-MS, and density functional theory calculations. Substituents with a positive inductive effect improved their stability at physiological pH (7.4) intensely, whereas substituents such as halogens accelerated hydrolysis and formation of dimeric pyrazolate and hydroxido bridged dimers. The observed cytotoxic profile is unusual, as complexes exhibited much higher cytotoxicity in SW480 colon cancer cells than in the broadly chemo- (incl. platinum-) sensitive CH1/PA-1 teratocarcinoma cells. This activity pattern as well as reduced or slightly enhanced ROS generation and the lack of DNA interactions indicate a mode of action different from established or previously investigated classes of metallodrugs.

NAPTHOQUINONES, PRO-DRUGS, AND METHODS OF USE THEREOF

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Paragraph 00156, (2017/07/06)

Provided herein are naphthoquinones compounds such as those with a hydrogen bond donating group of the formula (I): wherein: R1, R2, R3, R4, R5, and n are as defined herein. Also provided herein are pharmaceutical composition of the present compounds and methods of treatment using the compounds including their use in the treatment of cancer.

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