40914-11-2

Usage

Uses

Used in Pharmaceutical Synthesis:
2-CHLORO-N-(CYCLOHEXYLMETHYL)ACETAMIDE is used as a key intermediate in the synthesis of various pharmaceuticals due to its unique reactivity and structural properties. It contributes to the development of new drugs with improved therapeutic effects and reduced side effects.
Used in Agrochemical Production:
In the agrochemical industry, 2-CHLORO-N-(CYCLOHEXYLMETHYL)ACETAMIDE serves as a valuable building block for the creation of novel agrochemicals. Its incorporation into the molecular structures of these compounds enhances their effectiveness in pest control and crop protection.
Used in the Synthesis of 4-Oxo-Pentanoic Acid Derivatives:
2-CHLORO-N-(CYCLOHEXYLMETHYL)ACETAMIDE is utilized in the synthesis of 4-oxo-pentanoic acid derivatives, which exhibit potential biological activities. These derivatives may have applications in medicine, agriculture, and other fields, contributing to the discovery of new bioactive compounds.
Used in Research and Development:
2-CHLORO-N-(CYCLOHEXYLMETHYL)ACETAMIDE is employed as a research compound in various scientific studies. Its unique properties and reactivity make it a valuable tool for exploring new chemical reactions, understanding molecular mechanisms, and developing innovative applications in different industries.
Used as a Potential Local Anesthetic:
Owing to its mild physiological effect, 2-CHLORO-N-(CYCLOHEXYLMETHYL)ACETAMIDE has been investigated for its potential as a local anesthetic. Its ability to numb pain without causing significant side effects makes it a promising candidate for use in medical procedures and pain management.

InChI:InChI=1/C9H16ClNO/c10-6-9(12)11-7-8-4-2-1-3-5-8/h8H,1-7H2,(H,11,12)

Upstream product

• 79-04-9 chloroacetyl chloride 
• 3218-02-8 cyclohexylmethylamine 

Downstream Products

• 596808-06-9 2-(2-bromopyridin-3-yloxy)-N-cyclohexylmethylacetamide 

Relevant academic research and scientific papers

COVALENT TARGETING OF E3 LIGASES

Disclosed herein, inter alia, are compositions and methods for targeting E3 ligases. In an aspect is a targeted protein degrader including 1) a targeted protein binder and 2) an E3 Ubiquitin ligase binder, wherein the E3 Ubiquitin ligase is human RNF4 or human RNF114. In an aspect is provided a pharmaceutical composition including a compound as described herein, including embodiments, and a pharmaceutically acceptable excipient.

Gadolinium Complex of 1,4,7,10-Tetraazacyclododecane-N,N′,N″, N'''-1,4,7-trisacetic Acid (DO3A) Conjugate of Tranexamates: A Quest for a Liver-specific Magnetic Resonance Imaging Contrast Agent

The work is directed toward the synthesis of a series of DO3A conjugates of tranexamates (1c-e) and their Gd complexes (2c-e) for use as a liver-specific MRI CA. All these complexes show thermodynamic and kinetic stabilities comparable to those of structu

One-pot synthesis of pyridazino[1,4]oxazin-3-ones

Pyridazino[1,4]oxazin-3-ones were conveniently prepared in a one-pot condensation of N-substituted 2-chloroacetamides with various 5-chloro-pyridazin-6-ones via rearrangement of a spiro-aminoketal intermediate.

SUBSTITUTED HETEROCYCLIC COMPOUNDS

Disclosed are novel heterocyclic derivatives, useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, and myocardial infarction. The compounds are also useful in the treatment of diabetes.

Novel synthesis of pyridazino[4,5-b][1,4]oxazin-3,8-diones

A novel and effective synthesis of pyridazino[4,5-b][1,4]oxazin-3,8-diones via Smiles rearrangement is presented. Treatment of N-substituted 2-chloro(or hydroxy)acetamide, 2-tetrahydropyranyl-4-chloro-5-hydroxy(or chloro)pyridazin-3-one and cesium carbonate in refluxing acetonitrile was afforded the corresponding pyridazino[4,5-b][1,4]oxazin-3,8-diones in excellent yield.

A one-pot synthesis of pyrido[2,3.b][1,4]oxazin-2-ones

Pyrido[2,3-b][1,4]oxazin-2-ones are conveniently prepared in excellent yields by a one-pot annulation of N-substituted-2-chloroacetamides with 2-halo-3-hydroxypyridines with use of cesium carbonate in refluxing acetonitrile. The key transformation features a Smiles rearrangement of the initial O-alkylation product and subsequent cyclization.

Carbostyril derivative

Carbostyril compounds or salts thereof of the formula STR1 wherein A is a C1 -C6 alkylene group; R1 is a C3 -C8 cycloalkyl-C1 -C6 alkyl group which may have, as a substituent, a