40919-11-7

Upstream product

• 30568-32-2 2-(4-chlorophenyl)-2-methylpropanenitrile 
• 96-36-6 methyl phosphite 
• 109-73-9 N-butylamine 
• 81928-56-5 dimethyl p-chlorophenylisobutyrylphosphonate 
• 6258-30-6 2-(4-chlorophenyl)-2-methylpropanoic acid 

Downstream Products

• 63293-78-7 ethyl 2-{4-[2-(2-(4-chlorophenyl)-2-methylpropionylamino)-ethyl]-phenoxy}-2-methylpropionate 
• 1224868-18-1 C₁₃H₁₅ClN₂O 
• 63293-79-8 2-{4-[2-(2-(4-Chlorophenyl)-2-methylpropionylamino)ethyl]-phenoxy}-2-methylpropionic acid 
• 1190731-24-8 2-(4-chlorophenyl)-2,2-dimethyl-N-(4,4-diethoxybutyl)-acetamide 
• 1035260-93-5 diethyl 2-(2-(4-chlorophenyl)-2-methylpropanoyl)malonate 

Relevant academic research and scientific papers

Chiral 2-Aryl Ferrocene Carboxylic Acids for the Catalytic Asymmetric C(sp3)-H Activation of Thioamides

Enantioselective C-H functionalization reactions using trivalent group 9 metals (Co, Rh, Ir) have been investigated mainly on the basis of the development of well-designed chiral cyclopentadienyl (Cp) ligands. Although it has recently been demonstrated th

COMPOSITIONS USEFUL FOR TREATING DISORDERS RELATED TO KIT AND PDFGR

Compounds and compositions useful for treating disorders related to KIT and PDGFR are described herein.

3-ALKYLAMIDO-3-DEOXY-INGENOLS

wherein R1 is selected from the group consisting of hydrogen, methyl and ethyl; wherein R2 and R3 each independently are selected from the group consisting of hydrogen and (C1-C4)alkyl or wherein Rsu

Synthesis of 4H-1,3-Benzoxazines via Metal- and Oxidizing Reagent-Free Aromatic C-H Oxygenation

An unprecedented electrochemical aromatic C-H oxygenation reaction for the synthesis of 4H-1,3-benzoxazines from easily available N-benzylamides is reported. These oxidative cyclization reactions proceed in a transition metal- and oxidizing reagent-free fashion and produce H2 as only theoretical byproduct. Adapting the C-H oxygenation reaction in an electrochemical microreactor has been demonstrated.

Palladium(II)-catalyzed directed trifluoromethylthiolation of unactivated C(sp3)-H bonds

The synthesis of trifluoromethylthiolated aliphatic acid derivatives by Pd-catalyzed C(sp3)-H bond functionalization was developed. Using a bidentate directing group, the direct and selective introduction of a SCF3 moiety was possible on a range of amides with remarkable selectivity for C(sp3)-centers with an electrophilic SCF3 source and pivalic acid as an additive. This work constitutes an example of the unactivated C(sp3)-SCF3 bond formation by C-H activation offering a new access to relevant molecules.

A mild and general one-pot preparation of cyanoethyl-protected tetrazoles

Described herein is a mild and general one-pot procedure for the conversion of cyanoethyl amides to cyanoethyl-protected tetrazoles with azidotrimethylsilane via the intermediacy of imidoyl chlorides generated in situ with phosphorus pentachloride. This s

An investigation into the electrophilic cyclisation of N-acyl-pyrrolidinium ions: A facile synthesis of Pyrrolo-tetrahydroisoquinolones and Pyrrolo-benzazepinones

The triflic acid-mediated cyclisation of N-arylmethyl- and N-arylethyl-acylpyrrolidinium ions gave moderate to good yields of pyrrolo-tetrahydroisoquinolones and pyrrolo-benzazepinones respectively. Electron-donating R substituents enhanced the rate of reaction and gave higher yields than electron-withdrawing substituents. Substituents on the methyl or ethyl chain in general enhanced the reaction, unless sterically encumbered. The equivalent acylpiperidinium ions cyclised much slower and in lower yield.

CARBOXAMIDE DERIVATIVES AS ION CHANNEL MODULATORS

The present teachings provide compounds of Formula (I) wherein Ar, R1, R2, R3, X, p and n are defined herein. The present teachings also provide processes for producing said compounds and methods of treating a pathological condition or disorder, or alleviating a symptom thereof, using said compounds. The compounds can be useful in modulating ion channel activity including treating a variety of conditions associated with the abnormal modulation of one or more voltage-gated calcium channels.

Remote C-H bond functionalization reveals the distance-dependent isotope effect

Iodination of remote aryl C-H bonds has been achieved using palladium acetate as the catalyst and iodoacetate (IOAc) as the oxidant. Systematic kinetic isotope studies imply a mechanistic regime shift as the number of bonds separating the directing heteroatom and the target C-H bond increases. Both isotope and electronic effects observed in remote C-H bond activation are consistent with an electrophilic palladation pathway in which the initial palladation is slower than the C-H bond cleavage.

NAPHTHALENONE COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, COMPOSITIONS, AND USES THEREOF

Compounds of Formula (I) and Formula (II) are useful as inhibitors of HIF prolyl hydroxylases. Compounds of Formula(I) and Formula (II) have the following structures, where the definitions of the variables are provided herein.