40926-77-0

Basic information

• Product Name: (2-naphthyloxy)acetyl chloride
• Synonyms: (2-naphthyloxy)acetyl chloride;acetyl chloride, (2-naphthalenyloxy)-;2-(naphthalen-2-yloxy)acetyl chloride
• CAS NO: 40926-77-0
• Molecular Formula: C₁₂H₉ClO₂
• Molecular Weight: 220.65166
• Mol File: 40926-77-0.mol
• Article Data: 14

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2-naphthyloxy)acetyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: (2-naphthyloxy)acetyl chloride(40926-77-0)
• EPA Substance Registry System: (2-naphthyloxy)acetyl chloride(40926-77-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 40926-77-0(Hazardous Substances Data)

Usage

Uses

(2-Naphthyloxy)acetyl Chloride serves as one of the reagents for the discovery of indoline-2-carboxamide derivatives as new classs of brain-penetrant inhibitors of trypanosoma brucei. Also in preparation and antibacterial activity of N-(phenylquinazolinonyl) aryl-amides by amidation of amino(phenyl)quinazolone with aroyl chlorides

Upstream product

• 120-23-0 (2-naphthoyl)oxyacetic acid 
• 6036-14-2 ethyl (naphthalen-2-yloxy)acetate 
• 135-19-3 β-naphthol 

Downstream Products

• 67141-68-8 N-sec-butyl-2-(naphthalen-2-yloxy)acetamide 
• 349644-45-7 2-[2-(naphthalen-2-yloxy)-acetylamino]-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid ethyl ester 
• 1158842-78-4 C₄₆H₄₀N₂O₆ 
• 81012-92-2 N-hydroxysuccinimide 2-(naphthalen-2-yloxy)acetic acid ester 
• 1574223-26-9 N-(2-hydroxyphenyl)-3-(2-(naphthalen-2-yloxy)acetamido)propanamide 
• 300666-45-9 (S)-2,2'-bis(diphenylphosphinyl)-3,3'-binaphtho[2,1-b]furan 
• 300666-43-7 (+/-)-2,2'-bis(diphenylphosphino)-3,3'-binaphtho[2,1-b]furan 

Relevant articles and documents

Synthesis and biological evaluation of aryloxyacetamide derivatives as neuroprotective agents

A series of new aryloxyacetamide derivatives 10a-s and 14a-m are designed and synthesized. Their protective activities against the glutamate-induced cell death were investigated in differentiated rat pheochromocytoma cells (PC12 cells). Most compounds exhibited neuroprotective effects, especially for 10m, 10r, 14b and 14c, which showed potential protection of PC12 cells at three doses (0.1, 1.0, 10 μM). MTT assay, Hoechst 33342/PI double staining, and high content screening (HCS) revealed that pretreatment of the cells with 10m, 10r, 14b and 14c has significantly decreased the extent of cell apoptosis in a dose-dependent manner. The results of western blot analysis demonstrated these compounds suppressed apoptosis of glutamate-induced PC12 cells via caspase-3 pathway. These compounds can be lead compounds for further discovery of neuroprotective agents for treating cerebral ischemic stroke. Basic structure-activity relationships are also presented.

PYRAZOLE DERIVATIVES, PREPARATION METHOD THEREOF, AND COMPOSITION FOR PREVENTION AND TREATMENT OF OSTEOPOROSIS CONTAINING SAME

The present invention provides pyrazole derivative compounds and pharmaceutically acceptable salts thereof. The compounds of the present invention have an excellent effect of preventing and treating osteoporosis.

Synthesis and biological evaluation of some substituted amino thiazole derivatives

Condensation of acetophenone with thiourea in presence of halogen (Iodine) gives 2-amino-4-phenylthiazole (I). 2-Amino-4-phenyl-5-phenylazothizole (II) was prepared by coupling of phenyldiazonium chloride with 2-amino-4-phenylthiazole (I). A series of amide can be synthesized by treatment of appropriate substituted acid chlorides (III) with compound (II) using pyridine as solvent. All the synthesized compounds are characterized by the combination of elemental analysis and standard spectroscopic method. They are screened for anti-bacterial activity against Escherichia coli and Staphylococcus aureus as well as screened for antifungal activity against Aspergillus niger and Apergillus oryzae by cup plate method at 1μg/mL concentration in DMF. All the synthesized compounds showed moderate to good microbial activity.