40927-67-1Relevant academic research and scientific papers
1,3-Cycloaddition of benzonitrile oxides to diazepines.II. 1-Ethoxycarbonyl-4-methyl- and 6-methyl-1,2-diazepine
Beltrame, Paolo,Cadoni, Enzo,Floris, Costantino,Gelli, Gioanna
, p. 7001 - 7016 (2007/10/02)
Stable arylnitrile oxides (1b-e) and 1-ethoxycarbonyl-4-methyl and 6-methyl-1,2-diazepines (2f and 2h) undergo 1,3-cycloaddition reactions to give 1,2,4-oxadiazole derivatives (3) as the most abundant products. Secondary products of the class of isoxazoles (5 or 8) and 4,5-dihydroisoxazoles (6 or 7) were also identified. Overall kinetics were measured at 70.0°C, in mixtures of 1,1,2,2-tetrachloroethane and DMF; rate coefficients for the parallel reactions were obtained. Substituent and solvent effects are discussed.
