41322-69-4Relevant academic research and scientific papers
A method for synthesizing carbamate compounds by esterification reaction of amides and alcohols at room temperature
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Paragraph 0018-0021, (2022/01/10)
The present invention discloses a method of synthesizing a carbamate compound using an esterification reaction of an amide and an alcohol at room temperature, comprising the following steps, the amide, transition metal catalyst, alcohol dissolved in an organic solvent, at room temperature, stirred for 1-6 hours, to give a mixture; filter the mixture, concentrate the filtrate, by column chromatography, to give a carbamate compound. The method of the present invention directly utilizes a common, non-toxic amide as a substrate, a wide range of substrates. The reaction takes oxygen in the air as the oxidant, the reactants do not need to be excessive, the utilization rate of raw materials is high, the substrate range is wide, the reaction conditions are mild, the operation is simple, the time is short, the yield is high, and it is suitable for application in industrial production.
Synthesis of Simple Monocyclic 1,3-Diazepines from 1,2-Diazepines
Tsuchiya, Takashi,Kurita, Jyoji,Kojima, Hirokazu
, p. 444 - 445 (2007/10/02)
Thermolysis of the 1H-1,2-diazepines having an electron-donating substituent in the 4- or 6-position affords the corresponding 1,3-diazepines, whereas 1,2-diazepines having electron-withdrawing substituents do not show this ring-conversion.
