40929-75-7Relevant academic research and scientific papers
Asmic: An Exceptional Building Block for Isocyanide Alkylations
Alwedi, Embarek,Lujan-Montelongo, J. Armando,Pitta, Bhaskar R.,Chao, Allen,Cortés-Mejía, Rodrigo,Del Campo, Jorge M.,Fleming, Fraser F.
supporting information, p. 5910 - 5913 (2018/09/21)
Asmic addresses the long-standing challenge of alkylating isocyanides, providing access to isocyanides with diverse substitution patterns. The o-anisylsulfanyl group serves a critical dual role by facilitating deprotonation-alkylation and providing a latent nucleophilic site through an unusual arylsulfanyl-lithium exchange.
COMPOSITION, SYNTHESIS, AND USE OF A NEW CLASS OF ISONITRILES
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Paragraph 0055; 0093, (2015/09/23)
This invention relates to novel isonitriles, including arylthio isonitriles, and methods for their preparation. The isonitriles include a conjugated ring system. The structure is designed with the flexibility to have multiple substitution patterns. The isonitriles may be used in applications including, but not limited to, pharmaceutical compositions.
Synthesis of tripeptides containing α,α-diphenylglycine by the modified Ugi reaction
Yamada, Takashi,Omote, Yuichiro,Yamanaka, Yoshinori,Miyazawa, Toshifumi,Kuwata, Shigeru
, p. 991 - 998 (2007/10/03)
The modified Ugi reaction has been developed to synthesize tripeptides containing α,α-diphenylglycine (Dph) together with bulky amino acids. By the use of diphenylmethanimine, N-benzyloxycarbonyl (Z) amino acids and isocyanides derived from amino acids, very crowded tripeptides such as Z- Aib-Dph-Aib-OMe, Z-Ac6c-Dph-Aib-OMe, Z-Dph-Dph-Dph-OMe, etc. have been synthesized.
