409313-68-4

Upstream product

• 409313-67-3 3-(3,5-dimethyl-piperazin-1-yl)-N,N-bis-(4-fluoro-phenyl)-propionamide 
• 16744-99-3 methyl N-(4-fluorophenyl)carbamate 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 330-91-6 bis-(4-fluoro-phenyl)-amine 

Downstream Products

• 409313-70-8 1-((2R,6S)-4-{3-[Bis-(4-fluoro-phenyl)-amino]-propyl}-2,6-dimethyl-piperazin-1-yl)-3-phenyl-propan-1-one 
• 409313-69-5 1-((2R,6S)-4-{3-[Bis-(4-fluoro-phenyl)-amino]-propyl}-2,6-dimethyl-piperazin-1-yl)-2-(3,4-dichloro-phenyl)-ethanone 

Relevant academic research and scientific papers

Dual probes for the dopamine transporter and σ1 receptors: Novel piperazinyl alkyl-bis(4′-fluorophenyl)amine analogues as potential cocaine-abuse therapeutic agents

Both dopamine uptake inhibitors and σ1 receptor antagonists have been implicated as potential pharmacotherapeutics for the treatment of cocaine abuse. While the dopamine uptake inhibitors may share with cocaine neurochemical mechanisms underlyi

[3-cis-3,5-dimethyl-(1-piperazinyl)alkyl]-bis-(4′-fluorophenyl)amine analogues as novel probes for the dopamine transporter

In a continuing effort to identify novel probes with which to study the dopamine transporter (DAT), we discovered that the σ receptor antagonist, rimcazole, binds with moderate affinity (Ki=224 nM) to the DAT. The results from previous SAR stud