40932-43-2

Basic information

• Product Name: 2-Chloro-3-methylaminopyridine
• Synonyms: 2-CHLORO-3-METHYLAMINOPYRIDINE;2-CHLORO-3-(AMINOMETHYL)PYRIDINE;2-CHLORO-3-METHYLAMINOPYRIDINE,=99%;2-Chloro-N-methylpyridin-3-amine;2-Chloro-3-methylaminepyridine;2-chloro-N-Methyl-3-PyridinaMine
• CAS NO: 40932-43-2
• Molecular Formula: C₆H₇ClN₂
• Molecular Weight: 142.59
• EINECS: 201-525-2
• Product Categories: pharmacetical;Pyridines
• Mol File: 40932-43-2.mol

Chemical Properties

• Boiling Point: 250.708 °C at 760 mmHg
• Flash Point: 105.425 °C
• Appearance: /
• Density: 1.25 g/cm³
• Vapor Pressure: 0.021mmHg at 25°C
• Refractive Index: 1.597
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 2-Chloro-3-methylaminopyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-3-methylaminopyridine(40932-43-2)
• EPA Substance Registry System: 2-Chloro-3-methylaminopyridine(40932-43-2)

Safety Data

• Hazardous Substances Data: 40932-43-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Chloro-3-methylaminopyridine is used as a key intermediate for the preparation of various drugs, including antihistamines, antifungal, and anti-inflammatory agents. Its role in drug synthesis is crucial due to its ability to contribute to the development of medications that address a broad spectrum of health conditions.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Chloro-3-methylaminopyridine serves as an intermediate in the manufacturing of pesticides and herbicides. Its application in this industry is significant for the production of effective crop protection agents that help ensure agricultural productivity and food security.

InChI:InChI=1/C6H7ClN2/c1-8-5-3-2-4-9-6(5)7/h2-4,8H,1H3

Upstream product

• 6298-19-7 2-chloro-3-aminopyridine 
• 74-88-4 methyl iodide 
• 209798-48-1 tert-butyl N-(2-chloro-3-pyridinyl)carbamate 
• 100062-14-4 N-(2-chloropyridin-3-yl)-4-methylbenzenesulfonamide 
• 106320-35-8 N-(2-chloro-[3]pyridyl)-N-methyl-toluene-4-sulfonamide 

Downstream Products

• 1225208-05-8 4-Hydroxy-1-methyl-3-(2-trifluoromethylphenyl)-1H-[1,5]naphthyridin-2-one 
• 1225208-28-5 methyl 3-{methyl-[2-(2-trifluormethyl-phenyl)-acetyl]-amino}-pyridine-2-carboxylate 
• 142670-95-9 N-Benzyl-3-(4-methoxyphenyl)-2-diphenylphosphinoyl-1H-pyrido<2,3-b><1,4>thiazine 
• 142670-94-8 N-Benzyl-3-(4-chlorophenyl)-2-diphenylphosphinoyl-1H-pyrido<2,3-b><1,4>thiazine 
• 142670-96-0 N-Benzyl-3-(2-furyl)-2-diphenylphosphinoyl-1H-pyrido<2,3-b><1,4>thiazine 
• 142670-91-5 N-Methyl-3-phenyl-2-diphenylphosphinoyl-1H-pyrido<2,3-b><1,4>thiazine 
• 142670-88-0 2-(N-Methyl-N-diphenylphosphinoylmethylamino)-2-chloropyridine 
• 623912-25-4 3-benzyloxymethyl-1-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine 
• 383901-46-0 1-[(2-chloro-3-pyridinyl)methylamino]-3-(phenylmethoxy)-2-propanol 
• 56291-51-1 2-amino-3-methylaminopyridine 

Relevant articles and documents

Development of P- And N-Chirogenic Ligands Based on Chiral Induction from a Phosphorus Donor to a Nitrogen Donor in Palladium Complexes

We herein designed and synthesized amino-phosphine ligands 1a-c, which bear a P-chirogenic group, (R)-PtBuMe, and an N-group (NHR) on the pyridylene backbone, as a novel class of chiral ligands possessing chirogenic donors. Ligand 1a (R = Me) stereoselectively coordinated with PdCl2 to predominantly afford the P- and N-chirogenic metal complex 4a having an RN,SP configuration. In contrast, ligands 1b (R = iPr) and 1c (R = tBu) produced a mixture of diastereomers derived from two possible N-centered configurations. In complex 4a, the N-centered configuration was efficiently controlled by the P-chirogenic center via through-space attractive interactions between P-tBu and N-Me. Buried volume analysis indicated that this novel ligand creates a unique C1-symmetric chiral environment derived from both steric and electronic asymmetry.

Synthesis and Characterization of Highly Efficient Solution-Processable Green Ir(III) Complexes with High Current Efficiency and Very Low Efficiency Roll-Off

Three new highly efficient green-emitting heteroleptic phosphorescent iridium(III) complexes are designed and synthesized for the fabrication of solution-processable phosphorescent organic light-emitting diodes (PHOLEDs). Their photophysical, thermal, and electroluminescent (EL) properties are systematically investigated. The Ir(III) complexes comprise an amide-bridged trifluoromethyl (?CF3)-substituted phenylpyridine unit as the main ligand and picolinic acid (pic) and tetraphenylimidodiphosphinate (tpip) as ancillary ligands. In addition, the 2-ethoxyethnol (EO2?) solubilizing group is attached to the 4-position of pic ancillary ligand via tandem reaction, which improved the absolute photoluminescence quantum yields (PLQYs) and EL performance. The high-performance solution-processable PHOLEDs based on the bis[5-methyl-8-trifluoromethyl-5H-benzo(c)(1,5)naphthyridin-6-one](4-(2-ethoxyethoxy picolinate) iridium(III) (Ir1) complex exhibit a maximum external quantum efficiency (EQE) of 24.22% and a maximum current efficiency (CE) of 92.44 cd A?1, with the latter being among the best reported CEs achieved though solution processing. In contrast, PHOLEDs with the bis[5-hexyl-8-trifluoromethyl-5H-benzo(c)(1,5)naphthyridin-6-one] (tetraphenylimidodiphosphinato)iridium (Ir3) complex show extremely low efficiency roll-off, with an EQEmax of 19.40% and an EQE of 19.29% at 10 000 cd m?2.

Novel Iridium complex and organic light emitting device comprising the same

The present invention provides a novel iridium complex compound and an organic light emitting device using the same. The iridium complex compound represented by chemical formula 1 can be used as a material of an organic material layer of the organic light emitting device, can be used in a solution process, and can improve efficiency in the organic light emitting device.COPYRIGHT KIPO 2020

HYDROXYL PURINE COMPOUNDS AND USE THEREOF

Disclosed are a series of hydroxyl purine compounds and the use thereof as PDE2 or TNFα inhibitors, in particular, the compounds as shown in formula (I), or tautomers or pharmaceutically acceptable salts thereof.

HYDROXYL PURINE COMPOUNDS AND USE THEREOF

Disclosed are a series of hydroxyl purine compounds and the use thereof as PDE2 or TNFα inhibitors, in particular, the compounds as shown in formula (I), or tautomers thereof or pharmaceutically acceptable salts thereof.

Synthesis of imidazo[4,5-b]pyridines and imidazo[4,5-b]pyrazines by palladium catalyzed amidation of 2-chloro-3-amino-heterocycles

A facile synthesis of imidazo[4,5-b]pyridines and-pyrazines is described using a Pd-catalyzed amide coupling reaction. This reaction provides quick access to products with substitution at N1 and C2. A model system relevant to the natural product pentosidi

INDOLE DERIVATIVES WITH AN IMPROVED ANTIPSYCHOTIC ACTIVITY

The present invention relates to a novel indol derivative according to Formula (I) a pharmaceutically acceptable acid or base addition salt thereof, a stereochemically isomeric form thereof, an N-oxide form thereof or a quaternary ammonium salt thereof, w

Compounds for treating impaired fundic relaxation

The present invention concerns compounds of formula (I) a stereochemically isomeric form thereof, an N-oxide form thereof or a pharma-ceutically acceptable acid addition salt thereof, wherein —a1═a2—a3═a4— is a bivalent radical wherein one or two of a1 to a4 are nitrogen and the remaining a1 to a4 are —CH═; —Z1—Z2— is a bivalent radical; —A— is a bivalent radical of formula —N(R6)—Alk2— or a 5, 6 or 7-membered saturated heterocycle containing one or two nitrogen atoms; R1, R2 and R3 are each independently selected from hydrogen, C1-6alkyl, hydroxy, halo and the like; Alk1 and Alk2 are optionally substituted C1-6alkanediyl; R5 is a radical of formula (d-1), (d-2), (d-3), (d-4), (d-5) wherein n is 1 or 2; p1 is 0, and p2 is 1 or 2; or p1 is 1 or 2, and p2 is 0; X is oxygen, sulfur or ═NR9; Y2 is oxygen or sulfur; R7 is hydrogen, C1-6alkyl, C3-6cycloalkyl, phenyl or phenylmethyl; R8 is C1-6alkyl, C3-6cycloalkyl phenyl or phenylmethyl; R9 is cyano, C1-6alkyl, C3-6cyclo-alkyl, C1-6alkyloxycarbonyl or aminocarbonyl; R10 is hydrogen or C1-6alkyl; and Q is a bivalent radical. Processes for preparing said products, formulations comprising said products and their use as a medicine are disclosed, in particular for treating conditions which are related to disturbed fundic accomodation.

Ortho-hydroxyalkylation of aminopyridines: A novel approach to heterocycles

Reaction of 6-substituted N-alkyl-3-aminopyridines with aldehydes in the presence of dichlorophenylborane gives selectively 2-hydroxyalkyl-3- aminopyridines. Dehydration of the latter under pyrolytic or Lewis acid conditions generates a quinone methide imine intermediate which can undergo electrocyclic or [4+2] cycloaddition reactions to give naphthyridines, dihydronaphthyridines or tetrahydronaphthyridines. Palladium-catalyzed cyclization of the 2-(1-hydroxyallyl)-3-aminopyridines gives the corresponding 4-azaindoles.