409335-14-4

Upstream product

• 409335-12-2 (S)-(+)-1-(2,3-dihydroxypropyl)-pyrrolidin-2-one 
• 17201-66-0 N-(2,3-epoxypropyl)-α-pyrrolidone 
• 2687-97-0 1-allyl-2-pyrrolidinone 

Relevant academic research and scientific papers

Synthesis of the enantiomers of 1-{2-Hydroxy-3-[4-(2-hydroxy-phenyl)- piperazin-1-yl ]-propyl}-pyrrolidin-2-one using soluble and polystyrene bound salenCo(III)OAc complexes as catalysts of hydrolytic kinetic resolution

The asymmetric synthesis of 1-{2-hydroxy-3-[4-(2-hydroxy-phenyl)-piperazin- 1-yl]-propyl}-pyrrolidin-2-one 3 is described. Enantiomers of compound 3 were synthesized by hydrolytic kinetic resolution (HKR) of racemic 1-oxiranylmethyl-pyrrolidin-2-one rac-2

Stereocontrolled synthesis of the enantiomers of 1-[2-hydroxy-3-(4-phenyl-1-piperazinyl)-propyl]-pyrrolidin-2-one

The asymmetric synthesis of 1-[2-hydroxy-3-(4-phenyl-1-piperazinyl)-propyl]-pyrrolidin-2-one 1 is described. Enantiomers of compound 1 were obtained using the Sharpless asymmetric dihydroxylation (AD) or hydrolytic kinetic resolution (HKR) methods. The enantiomers of compound 1, which were obtained by HKR had higher enantiomeric excesses than those which were synthesized by AD and epoxidation. The enantiomeric purity of the synthesized compounds was determinated by capillary electrophoresis.