409360-24-3Relevant academic research and scientific papers
Synthesis and Monoamine Transporter Binding of 2-(Diarylmethoxymethyl)-3β-aryltropane Derivatives
Xu, Lifen,Kulkarni, Santosh S.,Izenwasser, Sari,Katz, Jonathan L.,Kopajtic, Theresa,Lomenzo, Stacey A.,Newman, Amy Hauck,Trudell, Mark L.
, p. 1676 - 1682 (2004)
3β-Aryltropane analogues wherein the 2-position was substituted with various diarylmethoxyalkyl groups were synthesized and evaluated for binding at the dopamine transporter (DAT), serotonin transporter (SERT), norepinephrine transporter (NET), and muscar
Synthesis and biological evaluation of 2-substituted 3β-tolyltropane derivatives at dopamine, serotonin, and norepinephrine transporters
Xu, Lifen,Izenwasser, Sari,Katz, Jonathan L.,Kopajtic, Theresa,Klein-Stevens, Cheryl,Zhu, Naiju,Lomenzo, Stacey A.,Winfield, Leyte,Trudell, Mark L.
, p. 1203 - 1210 (2007/10/03)
A series of eight 2-substituted 3-tolyltropane derivatives were synthesized, and the in vitro and in vivo biological activities as dopamine uptake inhibitors were determined. From the in vitro structure-activity data, it is apparent that a tolyl group in
