187093-02-3Relevant academic research and scientific papers
Design, synthesis and biological evaluation of 7-azatricyclodecanes: Analogues of cocaine
Tamiz, Amir P.,Smith, Miles P.,Kozikowski, Alan P.
, p. 297 - 300 (2000)
The synthesis and biological activity of a series of azatricyclodecane analogues of cocaine are described. All compounds studied in this series exhibit nanomolar potency and good selectivity for the serotonin transporter versus the dopamine transporter. (
Stereoselective synthesis of 2β-carbomethoxy-3β-phenyltropane derivatives. Enhanced stereoselectivity observed for the conjugate addition reaction of phenylmagnesium bromide derivatives with anhydro dichloromethane
Xu,Trudell
, p. 2037 - 2039 (2007/10/03)
The use of dichloromethane as a solvent for the conjugate addition reaction of preformed etheral solutions of phenylmagnesium bromide derivatives with anhydroecgonine methyl ester (2) was found to enhance the stereoselectivity of the reaction and provide the 2β-carbemethoxy-3β-phenyltropane derivatives 3a-d in high yield.
