409369-89-7Relevant academic research and scientific papers
Synthesis and biological evaluation of 4-amino derivatives of benzimidazoquinoxaline, benzimidazoquinoline, and benzopyrazoloquinazoline as potent IKK inhibitors
Beaulieu, Francis,Ouellet, Carl,Ruediger, Edward H.,Belema, Makonen,Qiu, Yuping,Yang, Xuejie,Banville, Jacques,Burke, James R.,Gregor, Kurt R.,MacMaster, John F.,Martel, Alain,McIntyre, Kim W.,Pattoli, Mark A.,Zusi, F. Christopher,Vyas, Dolatrai
, p. 1233 - 1237 (2007)
We have recently identified BMS-345541 (1) as a highly selective and potent inhibitor of IKK-2 (IC50 = 0.30 μM), which however was considerably less potent against IKK-1 (IC50 = 4.0 μM). In order to further explore the SAR around the
Methods of treating inflammatory and immune diseases using inhibitors of IκB kinase (IKK)
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, (2008/06/13)
The present invention describes methods of preventing and treating inflammatory and immune-related diseases or disorders using inhibitors of IκB kinase (IKK). Also described are IKK inhibitors effective for the prevention and treatment of inflammatory and
Methods of treating inflammatory and immune diseases using inhibitors of IkappaB kinase (IKK)
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, (2008/06/13)
The present invention describes methods of preventing and treating inflammatory and immune-related diseases or disorders using inhibitors of IκB kinase (IKK). Also described are IKK inhibitors effective for the prevention and treatment of inflammatory and
