Bioorganic and Medicinal Chemistry Letters p. 1233 - 1237 (2007)
Update date:2022-07-30
Topics:
Beaulieu, Francis
Ouellet, Carl
Ruediger, Edward H.
Belema, Makonen
Qiu, Yuping
Yang, Xuejie
Banville, Jacques
Burke, James R.
Gregor, Kurt R.
MacMaster, John F.
Martel, Alain
McIntyre, Kim W.
Pattoli, Mark A.
Zusi, F. Christopher
Vyas, Dolatrai
We have recently identified BMS-345541 (1) as a highly selective and potent inhibitor of IKK-2 (IC50 = 0.30 μM), which however was considerably less potent against IKK-1 (IC50 = 4.0 μM). In order to further explore the SAR around the
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