40939-26-2Relevant academic research and scientific papers
Palladium-mediated C-N, C-C, and C-O functionalization of azolopyrimidines: a new total synthesis of variolin B
Baeza, Alejandro,Mendiola, Javier,Burgos, Carolina,Alvarez-Builla, Julio,Vaquero, Juan J.
, p. 4073 - 4077 (2008)
A new total synthesis of the alkaloid variolin B is achieved by a selective and sequential palladium-mediated functionalization of a trihalo-substituted pyrido[3′,2′:4,5]pyrrolo[1,2-c]pyrimidine. This intermediate is obtained by a new heterocyclization reaction between an appropriate bromomethyl azaindole and N-tosylmethyl dichloroformimide. The methodology may be effective for the synthesis of some analogs by substitution on the relatively unexplored C4 and C9 positions of the alkaloid.
Development of a One-Pot Synthetic Method for Multifunctional Oxazole Derivatives Using Isocyanide Dichloride
Soeta, Takahiro,Matsumoto, Akihiro,Sakata, Yoko,Ukaji, Yutaka
, p. 4930 - 4935 (2017/05/12)
A one-pot synthetic method was developed for multifunctional dihydrooxazole and oxazole derivatives. New reaction sequences were developed involving the formation of isocyanide dichloride, an aldol-type reaction with aldehydes, and a nucleophilic addition-elimination reaction, which efficiently afforded the dihydrooxazole and oxazole scaffolds.
A simple, general synthesis of carbonimidic dichlorides
Gober, Claire M.,Le, Hoang V.,Ganem, Bruce
experimental part, p. 4536 - 4537 (2012/09/25)
The reaction of aliphatic and aromatic isonitriles with sulfuryl chloride provides an efficient, general route to the corresponding dichlorides without byproducts of free-radical substitution.
Base-Induced Cycloaddition of N-(Tosylmethyl)imino Compounds to Michael Acceptors. Synthesis of 2,3,4-Trisubstituted Pyrroles
Houwing, Hendrik A.,van Leusen, Albert M.
, p. 1127 - 1132 (2007/10/02)
A series of N-(tosylmethyl)imino compounds has been prepared, and applied to a new, base induced, one operational synthesis of otherwise more difficulty accesible 2,3,4-trisubstituted pyrroles from electron deficient olefins.This regiospec
