40939-26-2Relevant articles and documents
Palladium-mediated C-N, C-C, and C-O functionalization of azolopyrimidines: a new total synthesis of variolin B
Baeza, Alejandro,Mendiola, Javier,Burgos, Carolina,Alvarez-Builla, Julio,Vaquero, Juan J.
, p. 4073 - 4077 (2008)
A new total synthesis of the alkaloid variolin B is achieved by a selective and sequential palladium-mediated functionalization of a trihalo-substituted pyrido[3′,2′:4,5]pyrrolo[1,2-c]pyrimidine. This intermediate is obtained by a new heterocyclization reaction between an appropriate bromomethyl azaindole and N-tosylmethyl dichloroformimide. The methodology may be effective for the synthesis of some analogs by substitution on the relatively unexplored C4 and C9 positions of the alkaloid.
A simple, general synthesis of carbonimidic dichlorides
Gober, Claire M.,Le, Hoang V.,Ganem, Bruce
experimental part, p. 4536 - 4537 (2012/09/25)
The reaction of aliphatic and aromatic isonitriles with sulfuryl chloride provides an efficient, general route to the corresponding dichlorides without byproducts of free-radical substitution.
