40941-31-9Relevant articles and documents
Synthesis and evaluation of compounds that induce readthrough of premature termination codons
Jung, Michael E.,Ku, Jin-Mo,Du, Liutao,Hu, Hailiang,Gatti, Richard A.
supporting information; experimental part, p. 5842 - 5848 (2011/10/18)
A structure-activity relationship (SAR) study was carried out to identify novel, small molecular weight compounds which induce readthrough of premature termination codons. In particular, analogs of RTC13, 1, were evaluated. In addition, hypothesizing that these compounds exhibit their activity by binding to the ribosome, we prepared the hybrid analogs 13 containing pyrimidine bases and these also showed good readthrough activity.
Polysubstituted 2-(bromomethyl)furans in the arbuzov reaction
Pevzner,Ignat'ev,Ionin
, p. 743 - 749 (2007/10/03)
α-Bromomethyl derivatives of ketoesters, dinitriles, and diesters of the furan series react with trimethyl phosphite under conditions of the Arbusov reaction with formation of the corresponding phosphonates. The same is true of phosphorylation of 2-(bromomethyl)-5-phenylfuran and its derivatives, containing alkoxycarbonyl, keto or cyano group in the β-position of the ring. Phosphorylation of 5-bromo-substituted 2-(bromomethyl)-3-(ethoxycarbonyl)-4-methylfuran phosphorylates by trimethyl phosphite occurs exclusively by the way substitution of the bromine atom of the bromomethyl group, bypassing the furan ring bromine. Comparison of the behavior of polysubstituted halofuran derivatives under conditions of the Arbuzov and Michaelis-Becker reactions is carried out. It is established that increasing conjugation chain of the molecule favors the Arbuzov phosphorylation, but induces a redox reaction with sodium diethyl phosphite.
