40941-60-4

Upstream product

• 5570-19-4 2-nitrophenylboronic acid 
• 20000-96-8 5-(2-nitrophenyl)-2-furaldehyde 
• 40105-90-6 [5-(2-nitrophenyl)furan-2-yl]methanol 
• 1899-24-7 5-bromo-2-furancarboxaldehyde 

Downstream Products

• 76220-66-1 2-Methyl-1-[5-(2-nitro-phenyl)-furan-2-ylmethyl]-pyridinium; bromide 
• 76233-90-4 [5-(2-Nitro-phenyl)-furan-2-ylmethyl]-tripropyl-ammonium; bromide 
• 76220-71-8 Trimethyl-[5-(2-nitro-phenyl)-furan-2-ylmethyl]-ammonium; bromide 
• 1338233-12-7 1-((5-(2-nitrophenyl)furan-2-yl)methyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbaldehyde 
• 1338233-10-5 5-fluoro-1-((5-(2-nitrophenyl)furan-2-yl)methyl)pyrimidine-2,4(1H,3H)dione 
• 1338233-21-8 5-fluoro-4-imino-1-((5-(2-nitrophenyl)furan-2-yl)methyl)-3,4-dihydropyrimidin-2(1H)-one 
• 1338233-20-7 4-imino-1-((5-(2-nitrophenyl)furan-2-yl)methyl)-3,4-dihydropyrimidin-2(1H)-one 
• 1338233-09-2 1-((5-(2-nitrophenyl)furan-2-yl)methyl)pyrimidine-2,4(1H,3H)dione 
• 76220-74-1 Triethyl-[5-(2-nitro-phenyl)-furan-2-ylmethyl]-ammonium; bromide 

Relevant academic research and scientific papers

PREMATURE-TERMINATION-CODONS READTHROUGH COMPOUNDS

Premature termination codons readthrough compounds, composition thereof, and methods of making and using the same are provided.

Synthesis and evaluation of compounds that induce readthrough of premature termination codons

A structure-activity relationship (SAR) study was carried out to identify novel, small molecular weight compounds which induce readthrough of premature termination codons. In particular, analogs of RTC13, 1, were evaluated. In addition, hypothesizing that these compounds exhibit their activity by binding to the ribosome, we prepared the hybrid analogs 13 containing pyrimidine bases and these also showed good readthrough activity.