40956-06-7Relevant academic research and scientific papers
An investigation into domino-Heck reactions of N-acylamino-substituted tricyclic imides: Synthesis of new prospective pharmaceuticals
Bagdatli, Emine,Oecal, Nueket,Kaufmann, Dieter E.
, p. 2380 - 2385 (2007)
Heck and domino-Heck reactions of unsaturated N-acylamino-substituted tricyclic imides with aryl(heteroaryl) iodides and phenyl- or (trimethylsilyl)acetylene were either carried out in the presence of formate or phenyl- and (trimethylsilyl)acetylene, respectively. The C-C coupling reactions appeared to be completely diastereoselective, giving the corresponding N-acylamino-5-exo-aryl (heteroaryl)- (5a-c, 6a,b), N-(benzoylamino)-5-exo- phenyl-6-exo-[(trimethylsilyl)ethynyl]- (5d), or 5-exo-(4-chlorophenyl)-N-(2,2- dimethylpropanoylamino)-6-exo-(phenylethynyl)bicyclo[2.2.1]heptane-2-endo, 3-endo-dicarboximide (6c) (Schemes 3 and 4).
