40957-92-4Relevant academic research and scientific papers
Isolation of a new toxin, prosurugatoxin, from the toxic Japanese ivory shell, Babylonia japonica
Kosuge,Tsuji,Hirai,Fukuyama,Nukaya,Ishida
, p. 2890 - 2895 (1985)
A new toxin, named prosurugatoxin because it formed surugatoxin on decomposition, was isolated from the toxicated Japanese ivory shell (Babylonia japonica). Prosurugatoxin evoked mydriasis in mice at a minimum effective intraperitoneal dose of 15 ng/g body weight, and inhibited the contractile response of isolated guinea pig ileum induced by 3 x 10-5 g/ml of nicotine at a concentration of 5 x 10-9 g/ml. In this mollusc the prosurugatoxin content was about 5 times that of neosurugatoxin. Prosurugatoxin was deduced on the basis of physical and chemical data to be des-xylopyranosyl-neosurugatoxin.
Total Synthesis of (+/-)-Surugatoxin
Inoue, Shoji,Okada, Kunisuke,Tanino, Hideo,Hashizume, Kiyomatsu,Kakoi, Hisae
, p. 2729 - 2752 (2007/10/02)
Total synthesis of surugatoxin 1, isolated from the toxic Japanese ivory shell (Babylonia japonica), was achieved from 6-bromoisatin by a stepwise ring construction involving two key steps: the stereospecific cyclization (17 -> 18) and hydration (33b -> 1).
SYNTHESIS OF (+/-)-PROSURUGATOXIN AND RING TRANSFORMATION OF PROSURUGATOXIN INTO SURUGATOXIN
Inoue, Shoji,Okada, Kunisuke,Tanino, Hideo,Kakoi, Hisae
, p. 701 - 712 (2007/10/02)
Synthetic identification of prosurugatoxin and a possible mechanism for the ring transformation of prosurugatoxin into surugatoxin are presented.
TOTAL SYNTHESIS OF (+/-)-SURUGATOXIN
Inoue, Shoji,Okada, Kunisuke,Tanino, Hideo,Hashizume, Kiyomatsu,Kakoi, Hisae
, p. 4407 - 4410 (2007/10/02)
Total synthesis of surugatoxin 1, isolated from the toxic Japanese ivory shell (Babylonia japonica), was achieved from 6-bromoisatin by stepwise ring construction involving two key steps: the stereospecific cyclization(9->10) and hydration (17->1).
