Chemical and Pharmaceutical Bulletin p. 2890 - 2895 (1985)
Update date:2022-08-10
Topics:
Kosuge
Tsuji
Hirai
Fukuyama
Nukaya
Ishida
A new toxin, named prosurugatoxin because it formed surugatoxin on decomposition, was isolated from the toxicated Japanese ivory shell (Babylonia japonica). Prosurugatoxin evoked mydriasis in mice at a minimum effective intraperitoneal dose of 15 ng/g body weight, and inhibited the contractile response of isolated guinea pig ileum induced by 3 x 10-5 g/ml of nicotine at a concentration of 5 x 10-9 g/ml. In this mollusc the prosurugatoxin content was about 5 times that of neosurugatoxin. Prosurugatoxin was deduced on the basis of physical and chemical data to be des-xylopyranosyl-neosurugatoxin.
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