Isolation of a new toxin, prosurugatoxin, from the toxic Japanese ivory shell, Babylonia japonica

Article abstract of DOI:10.1248/cpb.33.2890

A new toxin, named prosurugatoxin because it formed surugatoxin on decomposition, was isolated from the toxicated Japanese ivory shell (Babylonia japonica). Prosurugatoxin evoked mydriasis in mice at a minimum effective intraperitoneal dose of 15 ng/g body weight, and inhibited the contractile response of isolated guinea pig ileum induced by 3 x 10^-5 g/ml of nicotine at a concentration of 5 x 10^-9 g/ml. In this mollusc the prosurugatoxin content was about 5 times that of neosurugatoxin. Prosurugatoxin was deduced on the basis of physical and chemical data to be des-xylopyranosyl-neosurugatoxin.

Full text of DOI:10.1248/cpb.33.2890

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