40958-82-5

Usage

Structure

A one-carbon chain with two nitrogen atoms at positions 1 and 2 on the ring

Common uses

As a precursor in the synthesis of organic compounds, a reagent in chemical reactions, and a catalyst in some chemical reactions

Applications

Pharmaceutical industry for the production of certain drugs, and in the field of organic chemistry for the preparation of heterocyclic compounds

Versatility

Valuable for a range of industries due to its catalytic properties and its use in the synthesis of organic compounds and drug production.

InChI:InChI=1/C3H3N2.Na/c1-2-4-5-3-1;/h1-3H;/q-1;+1

Upstream product

• 288-13-1 NH-pyrazole 
• 7646-69-7 sodium hydride 
• 148977-74-6 sodium amidotrihydridoborate 
• 56850-91-0 methyl 4-(2-bromoethoxy)benzoate 

Downstream Products

• 2406-25-9 di-tert-butyl nitroxide 
• 317808-26-7 1,2,4,5-tetrakis(pyrazol-1-yl)benzene 
• 120214-43-9 {Ru(CO)2(N₂C₃H₃)(PPh₃)}2 
• 98420-38-3 dicarbonylbis(triphenylphosphine)bis(μ-pyrazolyl)diiridium(I) 
• 92283-13-1 (Ir(CO)(P(C₆H₅)3)(C₃H₃N₂))2*C₆H₁₄ 
• 81274-22-8 Rh(C₃H₃N₂)(CS)(P(C₆H₁₁)3)2 
• 81274-21-7 Rh(C₃H₃N₂)(CS)(P(C₆H₅)3)2 
• 81014-18-8 4,8-bis(dimethylamino)-4,8-diphenylpyrazabole 
• 177562-55-9 Ru₂(CO)4(C₃H₃N₂)(C₃HN₂(CH₃)2)(P(C₆H₅)3)2 
• 102-54-5 ferrocene 
• 1264294-84-9 3-(4-chlorophenyl)-7-(2-methyl-1-phenyl-3-(1H-pyrazol-1-yl)propan-2-yl)pyrazolo[1,5-a]pyrimidine 
• 81760-64-7 [(COD)Rh(μ-pyrazolato)2Rh(P(OPh)3)2] 
• 190368-11-7 5-Methanesulfonyl-2-methyl-4-pyrazol-1-yl-benzoic acid 
• 1028263-43-5 3-Methanesulfonyl-4-pyrazol-1-yl-benzoic acid 

Relevant academic research and scientific papers

A practical synthetic method of O -(2-(Pyrazol-1-yl)pyridin-5-yl) methylhydroxylamine as a component of modithromycin

A practical synthesis of O-(2-(pyrazol-1-yl)pyridin-5-yl) methylhydroxylamine was achieved from the inexpensive raw materials, 2-chloro-5-chloromethylpyridine, pyrazole, and acetone oxime, using common reagents such as aq NaOH and sulfuric acid.

Structural classification of metal complexes with three-coordinate centres

Attempts to describe the geometry about three-coordinate silver(i) complexes have proven difficult because interatomic angles generally vary wildly and there is no adequate or readily available classification system found in the literature. A search of the Cambridge Structural Database shows that complexes formed between any metal centre and three non-metal donors (18001 examples) usually adopt geometries that are quite different than ideal 'textbook' extremes of either trigonal planar (～4% with α = β = γ = 120 ± 2°), T-shaped (～0.05% with α = 180 ± 2°, β = γ = 90 ± 2°), or trigonal pyramidal (～0.3% with α = β = γ = 110 ± 2°). Moreover, there are multiple variations of "Y-type" and "other" shapes that require elaboration. Thus, to assist in future structural descriptions, we developed a classification system that spans all known and yet-to-be-discovered three-coordinate geometries. A spreadsheet has also been constructed that utilizes the "shape-space" approach to extract the structural description from a user input of three angles about a tri-coordinate centre and the number of atoms in a plane. The structures of two silver(i) complexes of new N-donor ligands p-NH2C6H4C6H4CH(pz = pyrazol-1-yl)2, L1, and 2-ferrocenyl-4,5-di(2-pyridyl)imidazole, L2, illustrate the utility of this classification system.

Br?nsted and Lewis Base Behavior of Sodium Amidotrihydridoborate (NaNH2BH3)

The reactivity of sodium amidoborane (NaNH2BH3) as a Br?nsted and Lewis base was studied systematically. The [NH2BH3]– anion can act as a proton acceptor or a hydride donor in different types of reactions. In reactions with very weak Br?nsted acids such as cyclopentadiene, ammonia, and pyrazole, the [NH2BH3]– anion acts as a proton acceptor through the lone pair on N. The reactions of [NH2BH3]– with stronger Br?nsted acids are complicated. In the reaction with ammonium chloride or acetic acid, [NH2BH3]– accepts a proton, reforming NH3BH3. However, in the reaction with HCl or methanol, N–B bond cleavage occurs. [NH2BH3]– can also donate hydride in some reactions. The possible mechanisms of these reactions are discussed.

Poly(vinyl chloride) reactions with sodium and potassium derivatives of heteroaromatic and aromatic NH- and SH-acids in aprotic solvents

The observed featured and regularities of nucleophilic substitution of chlorine in poly(vinyl chloride) upon its reaction with sodium and potassium derivatives of pyrazole, 3,5-dimethylpyrazole, and 2-thiobenzimidazole, and with sodium thiophenolate have been understood in the frame of hard and soft acids and bases theory.

Synthesis and characterization of copper(II) complexes incorporating pyrazolyl-derived N,S-donor bidentate ligands

The novel bidentate N,S-donor anionic ligands [PhNCSIndz]-, [PhNCSImz]-, [PhNCSPzMe3]-, and [EtNCSPz]-, where Indz = indazole, Imz = imidazole, PzMe3 = 3,4,5-trimethylpyrazole, and Pz = pyrazole, were synthesized and used

2-(PYRAZOL-1-YL)PYRIDINE DERIVATIVE

Inventors found that a compound shown by formula: can be produced efficiently by using a compound shown by formula: (wherein R is a protected hydroxy or a group shown by: (wherein R1 is alkyl or optionally substituted aralkyl, and R2 is alkyl)).

2-(PYRAZOL-1-YL)PYRIDINE DERIVATIVE

A compound having the formula (1): can be produced with efficiency by using a compound represented by the formula (2): wherein R represents a protected hydroxyl group or a group represented by the formula (3): where R1 represents an alkyl group or an aralkyl group which may be substituted; and R2 represents an alkyl.

Antithrombotic agents

The invention relates to novel compounds of formula (I), and their pharmaceutically acceptable salts, as defined herein, processes and intermediates for their preparation, pharmaceutical formulations comprising the novel compounds of formula (I), and the use of the compounds of formula (I) as thrombin inhibitors.

The synthesis of some binuclear ruthenium(I) complexes bridged by anionic groups. X-ray structures of pyrazolate- and oxypyridinate-bridged complexes

A series of binuclear ruthenium(I) complexes, , have been prepared by two closely related routes.Complexes 2 (XY- = S2NC3H4-) and 3 (XY- = NC5H4O-) have been prepared by the reaction of with sodium 2-mercaptothiazolinate and sodium 2-oxypyridinate, respectively.The related pyrazolate-bridged complex 4 (XY- = N2C3H3-) was prepared by the reaction of sodium pyrazolate with followed by addition of PPh3.The X-ray structures of compounds 3 and 4 have been determined.Compound 3 crystallizes in the triclinic space group P1 with a 14.766(2), b 15.821(2), c 10.745(3) Angstroem, α 98.28(2) deg, β 11.99(2) deg, γ 103.29(1) deg, V 2209.1 Angstroem3, Z = 2.On the basis of 5521 unique observations (NO) and 379 parameters varied (NV) the structure has been refined to R = 0.042 and Rw = 0.054.Compound 4 crystallizes in the orthorombic space group P212121 with a 13.220(2), b 14.864(4), c 21.403(3) Angstroem, V 4200.7 Angstroem3 and Z = 4.This structure has been refined to R = 0.041 and Rw = 0.023 for NO = 3915 and NV = 546.Both structures display the sawhorse arrangement of carbonyl groups and have the phosphine ligands in the axial positions opposite the Ru-Ru binds.For 3 the oxypyridinate groups are bound in a head-to-tail arrangement.The two-atom pyrazolate bridge imparts more strain than the three-atom oxypyridinate bridge and as a result the equatorial planes of the Ru centers are tipped by only 16.2(4) deg in 3 but by 35.4(1) deg in 4.The Ru-Ru distances (2.7108(4) Angstroem (3); 2.732(1) Angstroem (4)) correspond to normal single bonds.