4097-20-5Relevant articles and documents
Cpecificy of Metylation by Dimethyl Sulfate of Barbituric Acid Salts and Alkyl Derivatives
Krasnov,Slesarev
, p. 543 - 548 (2007/10/03)
Metylation of mono- and dianionic forms of barbituric acid, its C- and N-alkyl derivatives with dimethylsulfate is studied. The methylation of monoanions occurs at the C5 carbon or O4(6) oxygen atoms, while that of dianions presumably at N1(3) nitrogen atoms. The selectivity of the dianions metylation at the nitrogen atoms increases in going from potassium to sodium and even more to lithium salts.
REACTION OF BARBITURIC ACID AND ITS METHYL DERIVATIVES WITH DIAZOMETHAN IN ETHERS
Krasnov, K. A.,Slesareva, V. I.,Studentsov, E. P.,Slesarev, V. I.
, p. 1765 - 1769 (2007/10/02)
A full scheme for the methylation of barbituric acid with diazomethane in diethyl ether, glyme, and THF was formulated.For barbituric acid and its N-methyl derivatives the reaction takes place at the oxygen atoms of the β-dicarbonyl fragment.The 6-methoxyuracil and its derivatives which are formed here are subsequently methylated at the nitrogen and oxygen atoms.The reaction takes place in accordance with the structures of the monoanions of the compounds being methylated.