40970-99-8Relevant articles and documents
2-Acetylpyridine thiosemicarbazones. 1. A new class of potential antimalarial agents
Klayman,Bartosevich,Griffin,Mason,Scovill
, p. 855 - 862 (2007/10/04)
Based on the antimalarial properties observed for 2-acetylpyridine 4-phenyl-3-thiosemicarbazone (1), an extensive series of related thiosemicarbazones was prepared and tested against Plasmodium berghei in mice. Screening results indicated that the presence of the 2-pyridylethylidene group was critical and that certain phenyl, benzyl, phenethyl, or cycloalkyl groups at N4 of the thiosemicarbazone moiety also contribute to antimalarial activity.