40977-08-0

Upstream product

• 36330-85-5 3-(p-phenyl)benzoylpropionic acid 
• 142335-89-5 5-(4-biphenyl)-2-(1,1-dimethylethoxy)furan 
• 92-66-0 4-bromo-1,1'-biphenyl 

Downstream Products

• 40885-07-2 4-Biphenyl-4-yl-N-(4-hydroxy-phenyl)-4-oxo-butyramide 
• 40885-10-7 4-Biphenyl-4-yl-4-oxo-N-(3-trifluoromethyl-phenyl)-butyramide 
• 40977-34-2 4-Biphenyl-4-yl-N-(2-hydroxy-phenyl)-4-oxo-butyramide 
• 40885-09-4 4-Biphenyl-4-yl-N-(4-ethoxy-phenyl)-4-oxo-butyramide 
• 40885-12-9 4-Biphenyl-4-yl-4-oxo-N-o-tolyl-butyramide 

Relevant academic research and scientific papers

Practical synthesis of fenbufen ethanolamide

The ongoing interest in ethanolamide derivatives of anti-inflammatory drugs as potential synthetic cannabinoids and mechanistic tools for the study of cannabinoid and vanilloid receptors prompted us to develop a practical gram scale synthesis for the hith

Synthesis, binding studies and molecular modeling of novel cannabinoid receptor ligands

In the present work, we report upon the design, synthesis and biological evaluation of new anandamide derivatives obtained by modifications of the fatty acyl chain and/or of the ethanolamide 'tail'. The compounds are of the general formula: 6-(substituted

2-Trialkylstannyl-5-tert-butoxyfurans: Convenient 5-substituted-2(3H)-furanone synthons

A versatile and mild route on 5-substituted-2(3H)-furanones (butenolides) from the palladium catalyzed coupling of aryl halides and 2-trialkylsannyl-5-tert-butoxyfurans is described.

A new non-steroidal anti-inflammatory analgesic: γ-oxo(1,1'-biphenyl)-4-butanoic acid (fenbufen)

100 analogs of γ-oxo(1,1'-biphenyl)-4-butanoic acid (fenbufen) were prepared and tested using the carrageenin, polyarthritis, and UV erythema anti-inflammatory tests and the 2-phenyl-1,4-benzoquinone writhing and inflamed paw pressure analgesic tests. Only three retained the same full spectrum of activity as fenbufen: dl-4-(4-biphenyl)-4-hydroxybutyric acid, dl-4-(4-biphenylyl)-1,4-butanediol, and 4-biphenylacetic acid. Fenbufen had the same spectrum of activity as acetylsalicylic acid (ASA), phenylbutazone, and indomethacin in the five tests. In addition, dose-response derived potencies show fenbufen more potent than ASA and at least as potent as phenylbutazone in all five tests.