40979-91-7Relevant academic research and scientific papers
Mpsc6 binuclear complexes immobilized on graphene oxide for oxidation of lignin model compounds and lignin
Yang, Xiao-Jun,Zhou, Xue-Fei,Zou, Zheng-Rong
, p. 973 - 982 (2021/06/26)
An efficient process for the oxidative degradation of lignin using M-GO (MPSC6 binuclear complexes immobilized on graphene oxide) biomimetic catalysts in acetonitrile was developed in this work. Different M-GO catalysts (M=Co, Cu, Zn and Ni) were used to catalyze the depolymerization of lignin model compounds and organosolv lignin. The results showed that the immobilization of MPSC6 complexes on GO was favorable for regulating the valuable depolymerization of the model compounds and lignin. The optimal solid catalyst Co-GO exhibited high catalytic activity, which showed a 83.04% conversion of phenolic β-O-4 lignin model compound, a 91.26% conversion of veratryl alcohol and a 96.24% conversion of vanillyl alcohol with a catalyst/model compound ratio of 50 mg:10 mmol and a dosage of 15 mmol H2O2 at 80 °C for 3 h. The stuctural changes of organosolv lignin occurred in catalytic oxidation were analyzed in terms of O/C ratio, molecular weight and OH content of lignin samples, and a plausible mechanism involving the formation of aromatic products and muconolactone from lignin depolymerization over M-GO was also proposed.
Synthesis and anti-inflammatory activity of isoquebecol
Cardinal, Sébastien,Paquet-C?té, Pierre-Alexandre,Azelmat, Jabrane,Bouchard, Corinne,Grenier, Daniel,Voyer, Normand
, p. 2043 - 2056 (2017/03/23)
We report here the synthesis of isoquebecol, an unprecedented constitutional isomer of quebecol, a polyphenolic compound discovered in maple syrup. The methodology used to prepare isoquebecol involves, as key steps, the formation of a dibromoalkene from an α-ketoester precursor, followed by a double Suzuki-Miyaura reaction. The anti-inflammatory activity of isoquebecol was studied on macrophage cells by monitoring its ability to inhibit LPS-induced IL-6 secretion. Results show that this new compound has an improved bioactivity over that of its natural isomer. Precursors and derivatives of quebecol, isoquebecol and model analog 2,3,3-triphenylpropanol were also prepared and tested in this study. Comparison between the three series of compounds led to establishing new SARs concerning the aryl ring substitution pattern on the triarylpropanol scaffold and substructure functionalization.
A new convenient synthesis of 1-(3-hydroxy-4-methoxyphenyl)ethane-1,2- diol (iso-MHPG) and its enantiomers
Fisher, Adrian J.,Kerrigan, Frank
, p. 2959 - 2968 (2007/10/03)
A safe and efficient process has been developed for the multigram synthesis of 1-(3-hydroxy-4-methoxyphenyl)ethane-1,2-diol (iso-MHPG) 2, via osmium-catalysed dihydroxylation of 3-benzyloxy-4-methoxystyrene 5, and subsequent debenzylation. The methodology
