40992-76-5Relevant academic research and scientific papers
Diazaspiro derivative containing 3-trifluoromethyl-phenyl substituent group as well as preparation method and application thereof
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Paragraph 0120-0123, (2019/06/07)
The invention relates to the technical field of medicine preparation, in particular to a diazaspiro derivative containing a 3-trifluoromethyl-phenyl substituent group as well as a preparation method and application thereof. A mother nucleus structure in t
Synthesis and antitumor activities of novel 1,4-disubstituted phthalazine derivatives
Zhang, Shulan,Zhao, Yanfang,Liu, Yajing,Chen, Dong,Lan, Weihuan,Zhao, Qiaoling,Dong, Chengcheng,Xia, Lin,Gong, Ping
experimental part, p. 3504 - 3510 (2010/08/06)
In an attempt to develop potent and selective antitumor agents,a series of novel 1,4-disubstituted phthalazine derivatives was designed and synthesized. All the prepared compounds were screened for their cytotoxic activities against A549,HT-29 and MDA-MB-231 cell lines in vitro. Among them,seven compounds (7a7e,7j and 7i) displayed excellent selectivity for MDA-MB-231 cells with IC50 values in the nM range,a desirable range for pharmacological testing. The most promising compound,7a (IC50 = 3.79 μ M,2.32 μ M,0.84 nM),was 5.6-,10.8-and 6.9 × 104-times more active than PTK-787 (IC50 = 21.16 μ M,22.11 μ M,57.72 μ M),respectively.
BENZENESULFONAMIDE COMPOUNDS AND THEIR USE AS BLOCKERS OF CALCIUM CHANNELS
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Page/Page column 179-180, (2010/11/28)
The invention relates to piperidinyl and hexahydroazepinyl compounds of Formula (I): and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein R1-R3, Z and q are defined as set forth in the specification. The inve
Acetamides and benzamides that are useful in treating sexual dysfunction
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, (2008/06/13)
The present invention relates to the use of compounds of formula (I) for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction.
Acetamides and benzamides that are useful in treating sexual dysfunction
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Page 45, (2010/02/06)
The present invention relates to the use of compounds of formula (I) for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction.
Acetamides and benzamides that are useful in treating sexual dysfunction
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Page 70, (2008/06/13)
The present invention relates to the use of compounds of formula (I) for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction.
