40998-93-4Relevant academic research and scientific papers
Chemoselective Cross-Coupling of gem-Borazirconocene Alkanes with Aryl Halides
Bai, Songlin,Gao, Yadong,Jiang, Chao,Qi, Xiangbing,Yang, Chao
supporting information, p. 11506 - 11513 (2020/07/14)
The direct and chemoselective conversion of the carbon-metal bond of gem-dimetallic reagents enables rapid and sequential formation of multiple carbon-carbon and carbon-heteroatom bonds, thus representing a powerful method for efficiently increasing structural complexity. Herein, we report a visible-light-induced, nickel-catalyzed, chemoselective cross-coupling reaction between gem-borazirconocene alkanes and diverse aryl halides, affording a wide range of alkyl Bpin derivatives in high yields with excellent regioselectivity. This practical method features attractively simple reaction conditions and a broad substrate scope. Additionally, we systematically investigated a Bpin-directed chain walking process underlying the regioselectivity of alkylzirconocenes, thus uncovering the mechanism of the remote functionalization of internal olefins achieved with our method. Finally, DFT calculations indicate that the high regioselectivity of this reaction originates from the directing effect of the Bpin group.
Macrocyclization of biaryl-bridged peptides through late-stage palladium-catalyzed C(sp2)-H Arylation
Bai, Qingqing,Bai, Zengbing,Wang, Huan
supporting information, p. 8225 - 8228 (2019/10/11)
Macrocyclic peptides are promising scaffolds of bioactive compounds and clinical therapeutics. Herein, we develop a strategy for the macrocyclization of biaryl-bridged peptides through late-stage Pd-catalyzed C(sp2)-H arylation. This method dis
Potential organ- or tumor-imaging agents. XXII Acyl-labeled cholesterol esters
Seevers,Schwendner,Swayze,Counsell
, p. 618 - 621 (2007/10/02)
A series of cholesteryl phenylalkanoic esters was synthesized in which the acyl moiety served as the carrier for radioiodine. Tissue distribution studies in rats revealed that several of these radioiodinated esters selectively accumulated in steroid-secre
