4100-14-5 Usage
Uses
Used in Pharmaceutical Research:
Ethyl 1,2,3-thiadiazole-5-carboxylate is used as a building block in pharmaceutical research for the development of new drugs. Its unique chemical structure and potential biological activities, including antifungal, antimicrobial, and anti-inflammatory properties, make it a valuable component in creating novel therapeutic agents.
Used in Agrochemical Development:
In the agrochemical industry, ethyl 1,2,3-thiadiazole-5-carboxylate is utilized as a key intermediate in the synthesis of various agrochemicals. Its biological activities contribute to the development of effective products for crop protection and enhancement of agricultural yields.
Used in Organic Synthesis:
Ethyl 1,2,3-thiadiazole-5-carboxylate is employed as a versatile reagent in organic synthesis. Its unique chemical structure allows for exploration of the reactivity and properties of thiadiazole derivatives in a wide range of chemical reactions, facilitating the creation of diverse chemical compounds for various applications.
Used in Chemical Research:
As a chemical compound with distinctive structural features, ethyl 1,2,3-thiadiazole-5-carboxylate is used in chemical research to study the properties and reactivity of thiadiazole derivatives. This research aids in understanding the fundamental chemistry of these compounds and can lead to advancements in material science and related fields.
Check Digit Verification of cas no
The CAS Registry Mumber 4100-14-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,1,0 and 0 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 4100-14:
(6*4)+(5*1)+(4*0)+(3*0)+(2*1)+(1*4)=35
35 % 10 = 5
So 4100-14-5 is a valid CAS Registry Number.
InChI:InChI=1/C5H6N2O2S/c1-2-9-5(8)4-3-6-7-10-4/h3H,2H2,1H3
4100-14-5Relevant academic research and scientific papers
1,2,3-Thiadiazole substituted pyrazolones as potent KDR/VEGFR-2 kinase inhibitors
Tripathy, Rabindranath,Ghose, Arup,Singh, Jasbir,Bacon, Edward R.,Angeles, Thelma S.,Yang, Shi X.,Albom, Mark S.,Aimone, Lisa D.,Herman, Joseph L.,Mallamo, John P.
, p. 1793 - 1798 (2007/10/03)
KDR kinase inhibition is considered to play an important role in regulating angiogenesis, which is vital for the survival and proliferation of tumor cells. Recently we disclosed a structure-based kinase inhibitor design strategy which led to the identification of a new class of VEGFR-2/KDR kinase inhibitors bearing heterocyclic substituted pyrazolones as the core template. Instability in a rat S9 preparation and poor iv PK profiles for most of these inhibitors necessitated exploration of new pyrazolones to identify new analogs with improved metabolic stability. Optimization of the heterocyclic moiety led to the identification of the thiadiazole series of pyrazolones (D) as potent VEGFR-2/KDR kinase inhibitors. SAR modifications, kinase selectivity profiling, and structural elements for improved PK properties were explored. Oral bioavailability up to 29% was achieved in the rat. Modeling results based on the Glide XP docking approach supported our postulation regarding the interaction of the lactam segment of the pyrazolones with the hinge region of the KDR kinase.
