34780-29-5

Usage

Uses

Used in Pharmaceutical Production:
3-OXO-PROPIONIC ACID ETHYL ESTER is used as a key intermediate in the synthesis of various pharmaceuticals. Its reactivity and versatility in chemical reactions make it an essential component in the development of new drugs and medications.
Used in Perfumery:
In the fragrance industry, 3-OXO-PROPIONIC ACID ETHYL ESTER is employed as a fixative agent to enhance the longevity and stability of perfumes. Its fruity scent contributes to the overall aroma profile of various perfumes and colognes.
Used in Flavoring Agents:
3-OXO-PROPIONIC ACID ETHYL ESTER is used as a flavoring agent in the food and beverage industry. Its fruity odor adds a pleasant taste and aroma to various food products, making it a popular choice for flavor enhancement.
Used as a Solvent:
3-OXO-PROPIONIC ACID ETHYL ESTER is utilized as a solvent in various chemical processes and reactions. Its ability to dissolve a wide range of substances makes it a valuable component in the production of paints, coatings, and adhesives.
Used in Organic Synthesis:
As an intermediate in organic synthesis, 3-OXO-PROPIONIC ACID ETHYL ESTER plays a crucial role in the production of various organic compounds. Its reactivity and compatibility with other chemicals make it an indispensable component in the synthesis of dyes, plastics, and other specialty chemicals.
Safety Precautions:
It is important to handle 3-OXO-PROPIONIC ACID ETHYL ESTER with care due to its potential to cause irritation to the skin, eyes, and respiratory system. Proper safety measures, such as wearing protective gear and working in well-ventilated areas, should be taken to minimize the risk of exposure and ensure the safe use of this chemical compound.

InChI:InChI=1/C5H8O3/c1-2-8-5(7)3-4-6/h4H,2-3H2,1H3

Upstream product

• 141-78-6 ethyl acetate 
• 109-94-4 formic acid ethyl ester 
• 81077-09-0 2-diazo-3-hydroxypropanoic acid ethyl ester 
• 64-17-5 ethanol 
• 72793-38-5 2,2-dimethyl-4,6-dioxo-1,3-dioxane-5-carbaldehyde 
• 15568-87-3 5-(hydroxymethylene)-2,2-dimethyl-1,3-dioxan-4,6-dione 
• 763-69-9 ethyl 3-ethoxypropionate 
• 141-52-6 sodium ethanolate 
• 105-56-6 ethyl 2-cyanoacetate 
• 2033-24-1 cycl-isopropylidene malonate 
• 57042-08-7 Diethyl trans-hex-3-enedioate 
• 107-31-3 Methyl formate 
• 201230-82-2 carbon monoxide 
• 623-47-2 propynoic acid ethyl ester 

Downstream Products

• 7424-91-1 methyl 3,3-dimethoxypropionate 
• 70800-62-3 N-acetyl-sulfanilic acid-(6-oxo-1,6-dihydro-pyrimidin-2-ylamide) 
• 19875-04-8 2-methyl-3H-pyrimidin-4-one 
• 108-53-2 isocytosine 
• 56305-66-9 sulfanilic acid-(6-oxo-1,6-dihydro-pyrimidin-2-ylamide) 
• 18009-46-6 3-Benzyloxyimino-propionsaeure-ethylester 
• 59291-72-4 ethyl 3-phenyl-isoxazole-4-carboxylate 
• 132839-91-9 (+/-)-ethyl 3-cyano-3-hydroxypropionate 
• 120314-21-8 (Z)-ethyl 3-(2,3-dimethoxy-5-ethenylanilino)acrylate 
• 59132-81-9 Ethyl (E)-N-(α-cyanobenzyl)-3-aminopropenoat 
• 92-61-5 7-hydroxy-6-methoxy-2H-1-benzopyran-2-one 
• 623-73-4 diazoacetic acid ethyl ester 
• 14762-48-2 ethyl 2-diazo-3-oxo-propanoate 
• 1026516-59-5 4-(4-Bromo-phenyl)-2-formyl-3-oxo-butyric acid ethyl ester 

Relevant academic research and scientific papers

An improved and large scale synthesis of the natural coumarin scopoletin

Isovanillin was oxidized with magnesium monoperoxyphthalate to 4-methoxyresorcinol (2) and the latter was reacted with 3-oxo-propionic acid ethylester prepared in situ to give scopoletin (1). These reactions can be achieved in kg scale in high yields.

PYRAZOLO[1,5-a]PYRIMIDIN-7(4H)-ONE INHIBITORS OF DYNEIN

Pyrazolo[1,5-a]pyrimidin-7(4H)-ones of formula (I) inhibit intraflagellar transport and are useful as anticancer agents and as probes of the function of dynein-dependent systems.

α-Amino Acid-Isosteric α-Amino Tetrazoles

The synthesis of all 20 common natural proteinogenic and 4 otherα-amino acid-isosteric α-amino tetrazoles has been accomplished, whereby the carboxyl group is replaced by the isosteric 5-tetrazolyl group. The short process involves the use of the key Ugi tetrazole reaction followed by deprotection chemistries. The tetrazole group is bioisosteric to the carboxylic acid and is widely used in medicinal chemistry and drug design. Surprisingly, several of the common α-amino acid-isosteric α-amino tetrazoles are unknown up to now. Therefore a rapid synthetic access to this compound class and non-natural derivatives is of high interest to advance the field.

2-(1-HETEROARYLPIPERAZIN-4-YL)METHYL-1,4-BENZODIOXANE DERIVATIVES AS ALPHA2C ANTAGONISTS

Compounds of formula I (formula I), wherein A is an optionally substituted five-membered unsaturated heterocyclic ring containing 1, 2 or 3 N, O or S ring heteroatom(s) exhibit alpha2C antagonistic activity and are thus useful for the treatment of diseases or conditions of the peripheric or central nervous system.

Preparation method of 3-N,N-dimethylamino ethyl acrylate

The present invention provides a preparation method of 3-N,N-dimethylamino ethyl acrylate. According to the method, a 3-N,N-dimethylamino ethyl acrylate crude product and a polymerization inhibitor are mixed and subjected to reduced pressure distillation, and 3-N,N-dimethylamino ethyl acrylate is obtained; the polymerization inhibitor in use is composed two or more of 2,6-binitro p-cresol, o-sec-4,6-dinitrophenol, 2, 4-dimethyl-6-tertiary butyl phenol, 2,6-binitro-p-cresol, 2,2,6,6-tetramethylpiperidine nitric oxide, 2,2,6,6-tetramethyl-4-piperidone, N-methyl-2-pyrrolidone, dimethyl-thioltoluenediamine and an organic sulfonic acid compound. The specific polymerization inhibitor and the 3-N,N-dimethylamino ethyl acrylate crude product are selected and mixed to be subjected to reduced pressure distillation, the purity of 3-N,N-dimethylamino ethyl acrylate obtained through distillation is high, and the yield is also high.

Studies towards the synthesis of secoiridoids

A new approach to secoiridoids, based on the synthesis of the key functionalized intermediates 4 and 5, is presented. These compounds were tested in formal [3+3] cycloadditions. Acyl-chloride 15 was transformed into enol α,β-unsaturated ester 16, which was involved in a N-heterocyclic carbene rearrangement to give an advanced precursor 17 in the total synthesis of secoiridoids.

An efficient procedure for the synthesis of formylacetic esters

An efficient synthesis of formylacetic esters via ozonolysis of trans-β-hydromuconic esters followed by a solid-supported triphenylphosphine reduction has been developed. In addition, an extension toward formylacetic amides and a one-pot preparation of more stable intermediates which can be used for further transformations are also described.

New [11C]phosgene based synthesis of [11C]pyrimidines for positron emission tomography

Thymine, 5-FU, and uracil were successfully synthesized through a procedure involving a cyclocondensation of triphosgene with newly developed (α-substituted β-aminoacrylamides intermediates (1a, X= Me; 1b, X= F; 1c, X= H). The radioligands [2-11C]thymine and [2- 11C]5-fluorouracil were synthesized in high radiochemical yields in 16-17 minutes from the end of bombardment by applying the cyclocondensation method with [11C]COCl2.

METHOD FOR SYNTHESIS OF KETO ACID OR AMINO ACID BY HYDRATION OF ACETHYLENE COMPOUND

An object of the present invention is to provide a method for synthesis of keto acids by hydration of an acetylene compound (acetylene-carboxylic acids) under mild conditions free from harmful mercury catalysts and a method for synthesis of amino acids from acetylene-carboxylic acids in a single container (one-pot or tandem synthesis). In one embodiment of the method according to the present invention for synthesis of keto acids, acetylene-carboxylic acids is hydrated in the presence of a metal salt represented by General Formula (1), where M1 represents an element in Group VIII, IX, or X of the periodic table, and X1, X2, or X3 ligand represents halogen, H2O, or a solvent molecule, and k represents a valence of a cation species, and Y represents an anion species, and L represents a valence of the anion species, and each of K and L independently represents 1 or 2, and k × m = L × n.

PYRIDINYL-PYRIMIDINE DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATING AGENTS

This invention relates to novel pyridinyl-pyrimidine derivatives and their use as potassium channel modulating agents. Moreover the invention is directed to pharmaceutical compositions useful for the treatment or alleviation of diseases or disorders associated with the activity of potassium channels.