410095-16-8

Upstream product

• 74134-78-4 (2S,3R)-3,4-epoxy-1,2-O-isopropylidenebutane-1,2-diol 
• 88159-06-2 tert-butyl(diphenyl)(2-propynyloxy)silane 
• 91274-05-4 (2S,3S)-1,2-O-isopropylidene-1,2,3,4-tetrol 
• 94451-17-9 (2S,4'S)-2-(2',2'-Dimethyl-1',3'-dioxolan-4'-yl)-2-hydroxyethyl benzoate 
• 92973-39-2 O³,O⁴-(1-methylethylidene)-L-threonic acid 
• 92973-40-5 methyl (2R,3S)-3,4-O-isopropylidene-2,3,4-trihydroxybutanoate 
• 15042-01-0 5,6-O-isopropylidene-L-ascorbic acid 
• 410095-27-1 Benzoic acid (S)-2-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-methanesulfonyloxy-ethyl ester 

Downstream Products

• 410095-17-9 (2S,3R)-7-(tert-Butyl-diphenyl-silanyloxy)-3-(4-methoxy-benzyloxy)-hept-5-yne-1,2-diol 
• 410095-22-6 (2E,7E)-(5R,6S)-5-(4-Methoxy-benzyloxy)-8-((S)-4-methyl-3,6-dihydro-2H-pyran-2-yl)-6-triisopropylsilanyloxy-octa-2,7-dien-1-ol 
• 410095-25-9 (E)-(5R,6S)-5-(4-Methoxy-benzyloxy)-8-((S)-4-methyl-3,6-dihydro-2H-pyran-2-yl)-6-triisopropylsilanyloxy-oct-7-en-2-yn-1-ol 
• 410095-26-0 {(2S,3S)-3-[(E)-(2R,3S)-2-(4-Methoxy-benzyloxy)-5-((S)-4-methyl-3,6-dihydro-2H-pyran-2-yl)-3-triisopropylsilanyloxy-pent-4-enyl]-oxiranyl}-methanol 
• 410095-23-7 2,2-Dimethyl-propionic acid (2S,3R)-7-(tert-butyl-diphenyl-silanyloxy)-2-hydroxy-3-(4-methoxy-benzyloxy)-hept-5-ynyl ester 
• 410095-14-6 (2R,3R)-7-(tert-Butyl-diphenyl-silanyloxy)-3-(4-methoxy-benzyloxy)-2-triisopropylsilanyloxy-hept-5-ynal 
• 410095-24-8 (2S,3R)-7-(tert-Butyl-diphenyl-silanyloxy)-3-(4-methoxy-benzyloxy)-2-triisopropylsilanyloxy-hept-5-yn-1-ol 
• 410095-18-0 2,2-Dimethyl-propionic acid (2S,3R)-7-(tert-butyl-diphenyl-silanyloxy)-3-(4-methoxy-benzyloxy)-2-triisopropylsilanyloxy-hept-5-ynyl ester 
• 410095-21-5 (S)-2-[(E)-(3S,4R)-8-(tert-Butyl-diphenyl-silanyloxy)-4-(4-methoxy-benzyloxy)-3-triisopropylsilanyloxy-oct-1-en-6-ynyl]-4-methyl-3,6-dihydro-2H-pyran 

Relevant academic research and scientific papers

An improved synthesis of the C15-C28 fragment of laulimalide

The C15-C28 fragment of the paclitaxel-like antimicrotubule agent laulimalide has been synthesized in 12 linear steps from known epoxide 5, with an overall yield of 16%. The methyldihydropyran ring of the side chain was efficiently prepared using ring-closing olefin metathesis chemistry. The 19,20-diol stereochemistry originates in starting material 7 and the side chain was appended using a Kocienski-modified Julia coupling.