410095-25-9

Upstream product

• 410095-20-4 5-(6-methyl-3,7-dioxa-bicyclo[4.1.0]hept-4-ylmethanesulfonyl)-1-phenyl-1H-tetrazole 
• 410095-15-7 (S)-5-[(4-methyl-3,6-dihydro-2H-pyran-2-yl)methylsulfonyl]-1-phenyl-1H-tetrazole 
• 410095-19-1 5-(4-methyl-3,6-dihydro-2H-pyran-2-ylmethylsulfanyl)-1-phenyl-1H-tetrazole 
• 302554-87-6 (S)-2-allyloxy-4-methyl-1-trityloxy-4-pentene 
• 289472-96-4 (2S)-(4-methyl-3,6-dihydro-2H-pyran-2-yl)-methanol 
• 66335-71-5 (S)-4-methyl-1-trityloxymethyl-3,6-dihydro-2H-pyran 
• 410095-21-5 (S)-2-[(E)-(3S,4R)-8-(tert-Butyl-diphenyl-silanyloxy)-4-(4-methoxy-benzyloxy)-3-triisopropylsilanyloxy-oct-1-en-6-ynyl]-4-methyl-3,6-dihydro-2H-pyran 
• 410095-18-0 2,2-Dimethyl-propionic acid (2S,3R)-7-(tert-butyl-diphenyl-silanyloxy)-3-(4-methoxy-benzyloxy)-2-triisopropylsilanyloxy-hept-5-ynyl ester 
• 410095-24-8 (2S,3R)-7-(tert-Butyl-diphenyl-silanyloxy)-3-(4-methoxy-benzyloxy)-2-triisopropylsilanyloxy-hept-5-yn-1-ol 
• 410095-14-6 (2R,3R)-7-(tert-Butyl-diphenyl-silanyloxy)-3-(4-methoxy-benzyloxy)-2-triisopropylsilanyloxy-hept-5-ynal 
• 410095-23-7 2,2-Dimethyl-propionic acid (2S,3R)-7-(tert-butyl-diphenyl-silanyloxy)-2-hydroxy-3-(4-methoxy-benzyloxy)-hept-5-ynyl ester 
• 410095-17-9 (2S,3R)-7-(tert-Butyl-diphenyl-silanyloxy)-3-(4-methoxy-benzyloxy)-hept-5-yne-1,2-diol 
• 410095-16-8 (R)-5-(tert-Butyl-diphenyl-silanyloxy)-1-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-pent-3-yn-1-ol 

Downstream Products

• 410095-22-6 (2E,7E)-(5R,6S)-5-(4-Methoxy-benzyloxy)-8-((S)-4-methyl-3,6-dihydro-2H-pyran-2-yl)-6-triisopropylsilanyloxy-octa-2,7-dien-1-ol 
• 410095-26-0 {(2S,3S)-3-[(E)-(2R,3S)-2-(4-Methoxy-benzyloxy)-5-((S)-4-methyl-3,6-dihydro-2H-pyran-2-yl)-3-triisopropylsilanyloxy-pent-4-enyl]-oxiranyl}-methanol 

Relevant academic research and scientific papers

An improved synthesis of the C15-C28 fragment of laulimalide

The C15-C28 fragment of the paclitaxel-like antimicrotubule agent laulimalide has been synthesized in 12 linear steps from known epoxide 5, with an overall yield of 16%. The methyldihydropyran ring of the side chain was efficiently prepared using ring-closing olefin metathesis chemistry. The 19,20-diol stereochemistry originates in starting material 7 and the side chain was appended using a Kocienski-modified Julia coupling.