41019-17-4

Upstream product

• 1380395-14-1 N-benzyl-4-chloro-2-(phenylethynyl)aniline 
• 68-12-2 N,N-dimethyl-formamide 
• 928782-97-2 4-chloro-2-(phenylethynyl)aniline 
• 23746-76-1 5-chloro-2-phenylindole 

Downstream Products

• 82451-03-4 5-Chloro-2-phenyl-1H-indole-3-carbaldehyde oxime 
• 136230-32-5 (E)-3-(5-Chloro-2-phenyl-1H-indol-3-yl)-1-phenyl-propenone 
• 120607-74-1 (E)-3-(5-Chloro-2-phenyl-1H-indol-3-yl)-2-cyano-acrylic acid ethyl ester 
• 679836-33-0 coumarin-(5'-chloro-2'-phenylindole-3'-carboxaldehyde)-3-carbonylhydrazone 
• 120607-79-6 5-Amino-4-[1-(5-chloro-2-phenyl-1H-indol-3-yl)-meth-(Z)-ylidene]-4H-pyrazol-3-ol 
• 120607-89-8 4-(5-Chloro-2-phenyl-1H-indol-3-ylmethylene)-4H-pyrazole-3,5-diamine 
• 259223-22-8 C₁₆H₁₃ClN₄S 
• 1198475-83-0 C₂₃H₁₅Cl₂NO 
• 263891-70-9 C₂₄H₁₈ClNO 
• 1347738-23-1 (Z)-5-((5-chloro-2-phenyl-1H-indol-3-yl)methylene)thiazolidine-2,4-dione 
• 1347738-19-5 5-((5-chloro-2-phenyl-1H-indol-3-yl)methylene)pyrimidine-2,4,6(1H,3H,5H)-trione 
• 1347738-21-9 5-((5-chloro-2-phenyl-1H-indol-3-yl)methylene)-dihydro-2-thioxopyrimidine-4,6(1H,5H)-dione 
• 1347738-25-3 (4E)-4-((5-chloro-2-phenyl-1H-indol-3-yl)methylene)-3-methyl-1H-pyrazol-5(4H)-one 
• 1394139-23-1 2-amino-4,5-dimethyl-3-{N₁-[(2'-phenyl-5'-chloro-1H-indol-3'-yl)methylene]}thieno-3-carbohydrazide 

Relevant academic research and scientific papers

A copper(ii)-catalyzed annulative formylation of o-alkynylanilines with DMF: a single-step strategy for 3-formyl indoles

In this paper, a copper(ii)-catalyzed reaction of o-alkynylanilines with dimethylformamide (DMF) in the presence of oxygen has been developed for synthesizing multisubstituted 3-formyl indole scaffolds. This one-pot reaction proceeds through a cascade 5-endo-dig cyclization followed by formylation to construct 1,2-disubstituted 3-formyl indoles. The key aspects of this synthesis method are the broad substrate scope (with 38 examples), and well tolerating various functional groups. In addition, a detailed mechanism has been proposed, where DMF may serve as a carbon source for the in situ C3 formylation of the obtained indole derivatives.

An Efficient, Eco-Friendly Synthesis of Pyran Annulated Indole Analogs under Conventional Heating and Microwave Irradiation, and Their Anticancer and Antioxidant Activity

A rapid, facile, green, eco-friendly, cost effective, and efficient method for the synthesis of pyran annulated indole analogs via one-pot, three components reaction is developed. According to the developed method 2,5-disubstituted-1H-indol-3-carboxaldehyde, malononitrile and various phenols react under MW assisted solvent-free conditions. These compounds can be also prepared under a conventional method that is characterized by some disadvantages in comparison with the above approach. Structures of products are confirmed by FT-IR, 1H and 13C NMR, and mass spectral data. The in vitro antioxidant and cytotoxic activities of the products are evaluated against three tumor cell lines and discussed in terms of structure―activity analysis. Among the screened compounds 3d, 4a, 4b, 5a, and 5b exhibit excellent antioxidant activity. Compounds 4b, 5a, and 5b demonstrate strong cytotoxic activity.

Synthesis, antioxidant and DNA cleavage activities of novel indole derivatives

A new series of novel indole derivatives containing barbitone moiety (5a-i) are synthesized by simple and efficient condensation of chalcones (3a-i) with barbituric acid (4). The synthesized compounds are screened for their antioxidant (free radical scave

A New Route to Indoloisoquinolines

2-Phenylindole-3-carbaldoximes (2a-d) on cyclization with alcoholic sulphuric acid give δ-carbolines, indolo-isoquinolines (5a-d) and not the γ-carbolines.This constitutes a new route to δ-carbolines.