41019-44-7

Basic information

• Product Name: 5-(3-CHLORO-PHENYL)-FURAN-2-CARBOXYLIC ACID
• Synonyms: 5-(3-Chlorophenyl)furan-2-carboxylic acid, 2-Carboxy-5-(3-chlorophenyl)furan;2-Furancarboxylicacid, 5-(3-chlorophenyl)-;AKOS BAR-0042;5-(3-CHLOROPHENYL)-2-FUROIC ACID;5-(3-CHLORO-PHENYL)-FURAN-2-CARBOXYLIC ACID;ASISCHEM T31164;ART-CHEM-BB B025311;ZERENEX E/4047317
• CAS NO: 41019-44-7
• Molecular Formula: C₁₁H₇ClO₃
• Molecular Weight: 222.62
• Mol File: 41019-44-7.mol
• Article Data: 24

Chemical Properties

• Boiling Point: 398.6 °C at 760 mmHg
• Flash Point: 194.9 °C
• Appearance: /
• Density: 1.374 g/cm³
• Vapor Pressure: 4.55E-07mmHg at 25°C
• Refractive Index: 1.594
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 5-(3-CHLORO-PHENYL)-FURAN-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(3-CHLORO-PHENYL)-FURAN-2-CARBOXYLIC ACID(41019-44-7)
• EPA Substance Registry System: 5-(3-CHLORO-PHENYL)-FURAN-2-CARBOXYLIC ACID(41019-44-7)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 41019-44-7(Hazardous Substances Data)

Usage

Uses

5-(3-Chlorophenyl)-2-furoic acid is a reactant in the preparation of dantrolene (D185000) which has a potential to treat vascular dysfunction.

InChI:InChI=1/C11H7ClO3/c12-8-3-1-2-7(6-8)9-4-5-10(15-9)11(13)14/h1-6H,(H,13,14)

Upstream product

• 2527-99-3 methyl 5-bromo-2-furoate 
• 63503-60-6 3-chlorophenylboronic acid 
• 585-70-6 5-bromo-furan-2-carboxylic acid 
• 1899-24-7 5-bromo-2-furancarboxaldehyde 
• 98-01-1 furfural 
• 88-14-2 2-furanoic acid 
• 108-42-9 3-chloro-aniline 
• 22078-59-7 5-(3-chlorophenyl)-2-furancarboxaldehyde 
• 41019-39-0 5-(3-chlorophenyl)furan-2-carboxylic acid methyl ester 

Downstream Products

• 92973-26-7 5-(3-chlorophenyl)furan-2-carbonyl chloride 
• 80174-11-4 5-(3-Chloro-phenyl)-furan-2-carbonyl azide 
• 1354698-27-3 N-5-(3'-chlorophenyl)-2-furoyl-1H-1,2,4-triazole 
• 1354698-15-9 N-5-(3'-chlorophenyl)-2-furoyl-1H-pyrazole 
• 1403472-94-5 N-[3-(3-aminobenzyl)-2,4-dioxoimidazolidin-1-yl]-5-(3-chlorophenyl)-2-furamide hydrochloride 
• 1403472-79-6 5-(3-chlorophenyl)-N-(2,4-dioxo-3-methylimidazolidin-1-yl)-2-furamide 
• 1403473-45-9 N-{3-[3-(tert-butoxycarbonylamino)benzyl]-2,4-dioxoimidazolidin-1-yl}-5-(3-chlorophenyl)-2-furamide 
• 92973-06-3 {5-[5-(3-Chloro-phenyl)-furan-2-yl]-tetrazol-1-yl}-acetic acid ethyl ester 
• 93770-53-7 {5-[5-(3-Chloro-phenyl)-furan-2-yl]-tetrazol-1-yl}-acetic acid 
• 92972-95-7 {[1-Chloro-1-[5-(3-chloro-phenyl)-furan-2-yl]-meth-(Z)-ylidene]-amino}-acetic acid ethyl ester 
• 92973-16-5 {[5-(3-Chloro-phenyl)-furan-2-carbonyl]-amino}-acetic acid ethyl ester 
• 80173-99-5 [(E)-4-(3-Chloro-phenyl)-4-oxo-but-2-enoyl]-carbamic acid benzyl ester 

Relevant articles and documents

Derivatives of (R)-3-(5-Furanyl)carboxamido-2-aminopropanoic Acid as Potent NMDA Receptor Glycine Site Agonists with GluN2 Subunit-Specific Activity

NMDA receptors mediate glutamatergic neurotransmission and are therapeutic targets due to their involvement in a variety of psychiatric and neurological disorders. Here, we describe the design and synthesis of a series of (R)-3-(5-furanyl)carboxamido-2-am

Carbon–Carbon Bond Formation for the Synthesis of 5-Aryl-2-Substituted Furans Catalyzed by K3[Fe(CN)6]

An efficient method for the carbon–carbon bond formation at C-5 position of 2-substituted furans to provide a range of π-diverse 5-aryl-2-substituted furan derivatives in 58–80% yield has been reported. The method employs several advantages such as use of catalytic amount of K3[Fe(CN)6] under mild conditions and short reaction time with high yields. Also, a variety of anilines with a variety of functional groups can be employed for the synthesis of 5-aryl-2-substituted furans. Graphic Abstract: [Figure not available: see fulltext.]

Synthesis and bioactivity of phenyl substituted furan and oxazole carboxylic acid derivatives as potential PDE4 inhibitors

In this present study, a series of 5-phenyl-2-furan and 4-phenyl-2-oxazole derivatives were designed and synthesized as phosphodiesterase type 4 (PDE4) inhibitors. In vitro results showed that the synthesized compounds exhibited considerable inhibitory ac