41019-44-7

Usage

Uses

Used in Pharmaceutical Industry:
5-(3-CHLORO-PHENYL)-FURAN-2-CARBOXYLIC ACID is used as a reactant for the preparation of dantrolene (D185000), a drug with potential applications in treating vascular dysfunction. Dantrolene is known for its ability to improve blood flow and reduce the risk of cardiovascular diseases by targeting the smooth muscle cells in blood vessels.
In the development of dantrolene, 5-(3-CHLORO-PHENYL)-FURAN-2-CARBOXYLIC ACID plays a crucial role as a building block, contributing to the drug's overall structure and function. Its unique chemical properties allow for the formation of dantrolene, which can then be further modified and optimized for specific therapeutic applications.
By understanding the description and uses of 5-(3-CHLORO-PHENYL)-FURAN-2-CARBOXYLIC ACID, we can appreciate its significance in the pharmaceutical industry and its potential to contribute to the development of new drugs for the treatment of vascular dysfunction and other related conditions.

InChI:InChI=1/C11H7ClO3/c12-8-3-1-2-7(6-8)9-4-5-10(15-9)11(13)14/h1-6H,(H,13,14)

Upstream product

• 585-70-6 5-bromo-furan-2-carboxylic acid 
• 63503-60-6 3-chlorophenylboronic acid 
• 1899-24-7 5-bromo-2-furancarboxaldehyde 
• 98-01-1 furfural 
• 88-14-2 2-furanoic acid 
• 108-42-9 3-chloro-aniline 
• 22078-59-7 5-(3-chlorophenyl)-2-furancarboxaldehyde 
• 2527-99-3 methyl 5-bromo-2-furoate 
• 41019-39-0 5-(3-chlorophenyl)furan-2-carboxylic acid methyl ester 

Downstream Products

• 92973-26-7 5-(3-chlorophenyl)furan-2-carbonyl chloride 
• 80174-11-4 5-(3-Chloro-phenyl)-furan-2-carbonyl azide 
• 80173-79-1 [5-(3-Chloro-phenyl)-furan-2-yl]-carbamic acid benzyl ester 
• 80173-89-3 2-(3-Chloro-phenyl)-2-hydroxy-5-oxo-2,5-dihydro-pyrrole-1-carboxylic acid benzyl ester 
• 80173-99-5 [(E)-4-(3-Chloro-phenyl)-4-oxo-but-2-enoyl]-carbamic acid benzyl ester 
• 1354698-27-3 N-5-(3'-chlorophenyl)-2-furoyl-1H-1,2,4-triazole 
• 1354698-15-9 N-5-(3'-chlorophenyl)-2-furoyl-1H-pyrazole 
• 1403472-94-5 N-[3-(3-aminobenzyl)-2,4-dioxoimidazolidin-1-yl]-5-(3-chlorophenyl)-2-furamide hydrochloride 
• 1403472-79-6 5-(3-chlorophenyl)-N-(2,4-dioxo-3-methylimidazolidin-1-yl)-2-furamide 
• 1403473-45-9 N-{3-[3-(tert-butoxycarbonylamino)benzyl]-2,4-dioxoimidazolidin-1-yl}-5-(3-chlorophenyl)-2-furamide 
• 92973-06-3 {5-[5-(3-Chloro-phenyl)-furan-2-yl]-tetrazol-1-yl}-acetic acid ethyl ester 
• 93770-53-7 {5-[5-(3-Chloro-phenyl)-furan-2-yl]-tetrazol-1-yl}-acetic acid 

Relevant academic research and scientific papers

Derivatives of (R)-3-(5-Furanyl)carboxamido-2-aminopropanoic Acid as Potent NMDA Receptor Glycine Site Agonists with GluN2 Subunit-Specific Activity

NMDA receptors mediate glutamatergic neurotransmission and are therapeutic targets due to their involvement in a variety of psychiatric and neurological disorders. Here, we describe the design and synthesis of a series of (R)-3-(5-furanyl)carboxamido-2-am

Carbon–Carbon Bond Formation for the Synthesis of 5-Aryl-2-Substituted Furans Catalyzed by K3[Fe(CN)6]

An efficient method for the carbon–carbon bond formation at C-5 position of 2-substituted furans to provide a range of π-diverse 5-aryl-2-substituted furan derivatives in 58–80% yield has been reported. The method employs several advantages such as use of catalytic amount of K3[Fe(CN)6] under mild conditions and short reaction time with high yields. Also, a variety of anilines with a variety of functional groups can be employed for the synthesis of 5-aryl-2-substituted furans. Graphic Abstract: [Figure not available: see fulltext.]

Discovery of a series of 5-phenyl-2-furan derivatives containing 1,3-thiazole moiety as potent Escherichia coli β-glucuronidase inhibitors

Gut microbial β-glucuronidases have drawn much attention due to their role as a potential therapeutic target to alleviate some drugs or their metabolites-induced gastrointestinal toxicity. In this study, fifteen 5-phenyl-2-furan derivatives containing 1,3

Design, synthesis, and electrophysiological evaluation of NS6740 derivatives: Exploration of the structure-activity relationship for alpha7 nicotinic acetylcholine receptor silent activation

The α7 nicotinic acetylcholine receptor (nAChR) silent agonists, able to induce receptor desensitization and promote the α7 metabotropic function, are emerging as new promising therapeutic anti-inflammatory agents. Herein, we report the structure–activity

Shedding X-ray Light on the Role of Magnesium in the Activity of Mycobacterium tuberculosis Salicylate Synthase (MbtI) for Drug Design

The Mg2+-dependent Mycobacterium tuberculosis salicylate synthase (MbtI) is a key enzyme involved in the biosynthesis of siderophores. Because iron is essential for the survival and pathogenicity of the microorganism, this protein constitutes an attractiv

Thiazolidin-2-cyanamides derivatives as novel potent Escherichia coli β-glucuronidase inhibitors and their structure–inhibitory activity relationships

Gut microbial β-glucuronidases have the ability to deconjugate glucuronides of some drugs, thus have been considered as an important drug target to alleviate the drug metabolites-induced gastrointestinal toxicity. In this study, thiazolidin-2-cyanamide de

Synthesis and bioactivity of phenyl substituted furan and oxazole carboxylic acid derivatives as potential PDE4 inhibitors

In this present study, a series of 5-phenyl-2-furan and 4-phenyl-2-oxazole derivatives were designed and synthesized as phosphodiesterase type 4 (PDE4) inhibitors. In vitro results showed that the synthesized compounds exhibited considerable inhibitory ac

2-furoylamide compound and preparation and application thereof

The invention discloses a 2-furancarboxamide compound and a preparation method and application thereof. The 2-furancarboxamide compound is obtained by reacting a compound as shown in a formula II with9H-pyridino[3,4-b]indole in the presence of an acid-bin

Synthesis and SAR of 5-aryl-furan-2-carboxamide derivatives as potent urotensin-II receptor antagonists

The synthesis and biological evaluation as potential urotensin-II receptor antagonists of a series of 5-arylfuran-2-carboxamide derivatives 1, bearing a 4-(3-chloro-4-(piperidin-4-yloxy)benzyl)piperazin-1-yl group, are described. The results of a systemat

Novel S-Thiazol-2-yl-furan-2-carbothioate Derivatives as Potential T3SS Inhibitors against Xanthomonas oryzae on Rice

Bacterial leaf blight (BLB) caused by Xanthomonas oryzae pv oryzae (Xoo) is considered as the most destructive disease of rice. The use of bactericides is among the most widely used traditional methods to control this destructive disease. The excessive an