4103-60-0

Usage

Uses

Used in Pharmaceutical Industry:
2-Aminophenylacetamide is used as a building block for the synthesis of various pharmaceutical drugs. Its versatile chemical structure allows for the development of new drug candidates with potential therapeutic applications.
Used in Chemical Industry:
2-Aminophenylacetamide serves as an intermediate in the production of dyes and pigments. Its unique properties contribute to the color and stability of these products, making it a valuable component in the chemical industry.
Used in Medical Research:
2-Aminophenylacetamide is used in research for its potential analgesic and anti-inflammatory properties. Ongoing studies aim to explore its therapeutic potential in various medical conditions, further expanding its applications in the healthcare sector.
It is crucial to handle 2-Aminophenylacetamide with care, as it may pose risks to human health and the environment if not properly managed and disposed of.

InChI:InChI=1/C8H10N2O/c9-7-4-2-1-3-6(7)5-8(10)11/h1-4H,5,9H2,(H2,10,11)

Upstream product

• 861560-54-5 nitro-phenyl-acetic acid amide 
• 6591-61-3 (S)-Phenylglycine methyl ester 
• 31142-60-6 2-(2-nitrophenyl)acetamide 

Downstream Products

• 58884-30-3 (2-acetylamino-phenyl)-acetic acid amide 
• 62779-70-8 (1S)-1-phenylethylene-1,2-diamine 

Relevant academic research and scientific papers

Identification of Diketopiperazine-Containing 2-Anilinobenzamides as Potent Sirtuin 2 (SIRT2)-Selective Inhibitors Targeting the "selectivity Pocket", Substrate-Binding Site, and NAD+-Binding Site

The NAD+-dependent deacetylase SIRT2 represents an attractive target for drug development. Here, we designed and synthesized drug-like SIRT2-selective inhibitors based on an analysis of the putative binding modes of recently reported SIRT2-selective inhibitors and evaluated their SIRT2-inhibitory activity. This led us to develop a more drug-like diketopiperazine structure as a "hydrogen bond (H-bond) hunter" to target the substrate-binding site of SIRT2. Thioamide 53, a conjugate of diketopiperazine and 2-anilinobenzamide which is expected to occupy the "selectivity pocket" of SIRT2, exhibited potent SIRT2-selective inhibition. Inhibition of SIRT2 by 53 was mediated by the formation of a 53-ADP-ribose conjugate, suggesting that 53 is a mechanism-based inhibitor targeting the "selectivity pocket", substrate-binding site, and NAD+-binding site. Furthermore, 53 showed potent antiproliferative activity toward breast cancer cells and promoted neurite outgrowth of Neuro-2a cells. These findings should pave the way for the discovery of novel therapeutic agents for cancer and neurological disorders.

Benzo[1,8]naphthyridine derivatives, their preparation and compositions containing them

New benzo[b][1,8]naphthyridine derivatives of general formula (I), in which R1 is a hydrogen atom or a hydroxyl or alkyl radical, R2 is a hydrogen atom or an alkyl, fluoroalkyl, cycloalkyl (3 to 6 C), alkyloxy or alkylamino radical, R3 is a phenyl or phenylalkyl radical substituted with one or more halogen atoms or alkyl, cycloalkyl (3 to 6 C), alkyloxy, cyano, amino, alkylamino, dialkylamino, alkyloxyalkyl, hydroxyalkyl, hydroxyalkyloxy, methylenedioxy, aminoalkyl, alkylaminoalkyl or dialkylaminoalkyl radicals, or R3 is a heterocyclic radical, and R4 is a hydrogen atom or a fluorine atom, the alkyl radicals (1 to 4 C) being linear or branched, their salts, their preparation and compositions containing them. These new products are useful as antimicrobials, or in the treatment of AIDS. STR1