31142-60-6

Basic information

• Product Name: 2-(2-nitrophenyl)acetamide
• Synonyms: 2-(2-Nitrophenyl)acetamide; benzeneacetamide, 2-nitro-
• CAS NO: 31142-60-6
• Molecular Formula: C₈H₈N₂O₃
• Molecular Weight: 180.1607
• Mol File: 31142-60-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 397.3°C at 760 mmHg
• Flash Point: 194.1°C
• Density: 1.335g/cm³
• Vapor Pressure: 1.6E-06mmHg at 25°C
• Refractive Index: 1.596
• CAS DataBase Reference: 2-(2-nitrophenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-nitrophenyl)acetamide(31142-60-6)
• EPA Substance Registry System: 2-(2-nitrophenyl)acetamide(31142-60-6)

Safety Data

• Hazardous Substances Data: 31142-60-6(Hazardous Substances Data)

Usage

General Description

2-(2-nitrophenyl)acetamide, also known as o-nitroacetanilide, is a chemical compound with a molecular formula C8H8N2O3. It is a yellow crystalline solid with a melting point of 152-154°C. 2-(2-nitrophenyl)acetamide is used in organic synthesis and as an intermediate in the production of various pharmaceuticals. It is also used in the preparation of dyes and pigments. 2-(2-nitrophenyl)acetamide is considered to be potentially hazardous and should be handled with care, as it may cause skin and eye irritation upon contact. Additionally, it may be harmful if ingested or inhaled, and precautions should be taken to avoid exposure to this compound.

Upstream product

• 5455-59-4 2-Nitrobenzenesulfonamide 
• 22751-23-1 (2-nitrophenyl)acetyl chloride 
• 91818-65-4 acetoacetyl-(2-nitro-benzenesulfonyl)-amine 
• 3740-52-1 2-(2-nitrophenyl)acetic acid 

Downstream Products

• 4103-60-0 2-(2-aminophenyl)acetamide 
• 610-66-2 2-nitro-benzeneacetonitrile 
• 697306-56-2 2,2,2-trifluoro-N-[2-(2-nitrophenyl)ethyl]acetamide 
• 33100-15-1 2-(2-aminoethyl)nitrobenzene 
• 48108-93-6 β-(o-aminophenyl)ethylamine 
• 4203-26-3 (2-nitrobenzoyl)diazomethane 

Relevant articles and documents

Identification of Diketopiperazine-Containing 2-Anilinobenzamides as Potent Sirtuin 2 (SIRT2)-Selective Inhibitors Targeting the "selectivity Pocket", Substrate-Binding Site, and NAD+-Binding Site

The NAD+-dependent deacetylase SIRT2 represents an attractive target for drug development. Here, we designed and synthesized drug-like SIRT2-selective inhibitors based on an analysis of the putative binding modes of recently reported SIRT2-selective inhibitors and evaluated their SIRT2-inhibitory activity. This led us to develop a more drug-like diketopiperazine structure as a "hydrogen bond (H-bond) hunter" to target the substrate-binding site of SIRT2. Thioamide 53, a conjugate of diketopiperazine and 2-anilinobenzamide which is expected to occupy the "selectivity pocket" of SIRT2, exhibited potent SIRT2-selective inhibition. Inhibition of SIRT2 by 53 was mediated by the formation of a 53-ADP-ribose conjugate, suggesting that 53 is a mechanism-based inhibitor targeting the "selectivity pocket", substrate-binding site, and NAD+-binding site. Furthermore, 53 showed potent antiproliferative activity toward breast cancer cells and promoted neurite outgrowth of Neuro-2a cells. These findings should pave the way for the discovery of novel therapeutic agents for cancer and neurological disorders.

AMINE COMPOUNDS

The present invention provide a compound of the formula:wherein ring A represents an aromatic ring optionally having substituents; B, Y and Ya are the same or different and each represents a bond, etc.; R1 and R2 are the same or different and each represents a hydrogen atom, etc.; R3 represents a hydrogen atom, etc.; R4 and R5 are the same or different and each represents a hydrogen, etc.; R6 represents an indolyl group optionally having substituents; and Z and Za are the same or different and each represents a hydrogen atom, etc.; or a salt thereof or a prodrug thereof, having a somatostatin receptor binding inhibition activity and is useful for preventing and/or treating diseases associated with somatostatin.