410540-37-3Relevant academic research and scientific papers
MACROCYCLIC LRRK2 KINASE INHIBITORS
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Page/Page column 172; 173, (2016/04/09)
The present invention relates to novel macrocyclic compounds of formula (I) and compositions containing said compounds acting as kinase inhibitors, in particular as inhibitors of LRRK2 (Leucine-Rich Repeat Kinase 2). Moreover, the present invention provides processes for the preparation of the disclosed compounds, as well as methods of using them, for instance as a medicine or diagnostic agent, in particular for the treatment and/or diagnosis of diseases characterized by LRRK2 kinase activity such as neurological disorders including Parkinson's disease and Alzheimer's disease.
Asymmetric synthesis of the four possible fagomine isomers
Takahata, Hiroki,Banba, Yasunori,Ouchi, Hidekazu,Nemoto, Hideo,Kato, Atsushi,Adachi, Isao
, p. 3603 - 3607 (2007/10/03)
The asymmetric synthesis of fagomine and its congeners 1-4 has been achieved by catalytic ring-closing metathesis (RCM). The synthesis involved the construction of the piperidene-type chiral building block 5 followed by dihydroxylation, starting from the D-serine-derived Garner aldehyde 6.
Formal synthesis of FPA, a kainoid amino acid, via ketyl radical cyclization
Kamabe, Mitsuru,Miyazaki, Takayuki,Hashimoto, Kimiko,Shirahama, Haruhisa
, p. 105 - 111 (2007/10/03)
The formal synthesis of FPA, a kainoid amino acid, was performed through the SmI2 induced ketyl radical cyclization as the key step. The stereoselectivity was inverted in the presence or absence of the proton source.
Asymmetric synthesis of fagomine and its congeners
Banba, Yasunori,Abe, Chiemi,Nemoto, Hideo,Kato, Atsushi,Adachi, Isao,Takahata, Hiroki
, p. 817 - 819 (2007/10/03)
The total synthesis of fagomine and its congeners 1-3 has been achieved starting from D-serine-derived Garner aldehyde 5 by catalytic ring-closing metathesis (RCM) for the construction of the piperidine ring followed by dihydroxylation.
