410544-70-6

Basic information

• Product Name: methyl (2E)-3-(7-{[(4-fluorobenzyl)amino]carbonyl}-8-hydroxy[1,6]-naphthyridin-5-yl)-2-propenoate
• Synonyms: methyl (2E)-3-(7-{[(4-fluorobenzyl)amino]carbonyl}-8-hydroxy[1,6]-naphthyridin-5-yl)-2-propenoate
• CAS NO: 410544-70-6
• Molecular Weight: 381.363
• Mol File: 410544-70-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: methyl (2E)-3-(7-{[(4-fluorobenzyl)amino]carbonyl}-8-hydroxy[1,6]-naphthyridin-5-yl)-2-propenoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (2E)-3-(7-{[(4-fluorobenzyl)amino]carbonyl}-8-hydroxy[1,6]-naphthyridin-5-yl)-2-propenoate(410544-70-6)
• EPA Substance Registry System: methyl (2E)-3-(7-{[(4-fluorobenzyl)amino]carbonyl}-8-hydroxy[1,6]-naphthyridin-5-yl)-2-propenoate(410544-70-6)

Safety Data

• Hazardous Substances Data: 410544-70-6(Hazardous Substances Data)

Upstream product

• 410544-56-8 N-(4-fluorobenzyl)-8-hydroxy-5-bromo-1,6-naphthyridine-7-carboxamide 
• 292638-85-8 acrylic acid methyl ester 
• 6163-58-2 tris-(o-tolyl)phosphine 

Downstream Products

• 410544-78-4 N-(4-fluorobenzyl)-8-hydroxy-5-(5-oxo-1,4-thiazepan-7-yl)-[1,6]naphthyridine-7-carboxamide 
• 410544-69-3 N-(4-fluorobenzyl)-5-(2,6-dioxohexahydropyrimidin-4-yl)-8-hydroxy-[1,6]naphthyridine-7-carboxamide 

Relevant articles and documents

A series of 5-(5,6)-dihydrouracil substituted 8-hydroxy-[1,6]naphthyridine- 7-carboxylic acid 4-fluorobenzylamide inhibitors of HIV-1 integrase and viral replication in cells

Introduction of a 5,6-dihydrouracil functionality in the 5-position of N-(4-fluorobenzyl)-8-hydroxy-[1,6]naphthyridine-7-carboxamide 1 led to a series of highly active HIV-1 integrase inhibitors. These compounds displayed low nanomolar activity in inhibit