410544-75-1Relevant academic research and scientific papers
A series of 5-(5,6)-dihydrouracil substituted 8-hydroxy-[1,6]naphthyridine- 7-carboxylic acid 4-fluorobenzylamide inhibitors of HIV-1 integrase and viral replication in cells
Embrey, Mark W.,Wai, John S.,Funk, Timothy W.,Homnick, Carl F.,Perlow, Debbie S.,Young, Steven D.,Vacca, Joseph P.,Hazuda, Daria J.,Felock, Peter J.,Stillmock, Kara A.,Witmer, Marc V.,Moyer, Gregory,Schleif, William A.,Gabryelski, Lori J.,Jin, Lixia,Chen, I-Wu,Ellis, Joan D.,Wong, Bradley K.,Lin, Jiunn H.,Leonard, Yvonne M.,Tsou, Nancy N.,Zhuang, Linghang
, p. 4550 - 4554 (2005)
Introduction of a 5,6-dihydrouracil functionality in the 5-position of N-(4-fluorobenzyl)-8-hydroxy-[1,6]naphthyridine-7-carboxamide 1 led to a series of highly active HIV-1 integrase inhibitors. These compounds displayed low nanomolar activity in inhibit
Aza- and polyaza-naphthalenyl carboxamides useful as HIV integrase inhibitors
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, (2008/06/13)
Aza- and polyaza-naphthalenyl carboxamide derivatives including certain quinoline carboxamide and naphthyridine carboxamide derivatives are described. These compounds are inhibitors of HIV integrase and inhibitors of HIV replication, and are useful in the
