41055-96-3Relevant academic research and scientific papers
Palladium- and nickel-catalyzed kumada cross-coupling reactions of gem -difluoroalkenes and monofluoroalkenes with Grignard reagents
Dai, Wenpeng,Xiao, Juan,Jin, Guanyi,Wu, Jingjing,Cao, Song
, p. 10537 - 10546 (2015/02/19)
A novel Kumada-Tamao-Corriu cross-coupling reaction of gem-di- or monofluoroalkenes with Grignard reagents, with or without β-hydrogen atoms, in the presence of a catalytic amount of palladium- or nickel-based catalysts has been developed. The reaction is performed under mild conditions (room temperature or reflux in diethyl ether for 1-2 h) and leads to di-cross- or mono-cross-coupled products in good to high yields.
