41068-36-4

Basic information

• Product Name: 2'-CHLORO-4'-HYDROXYACETOPHENONE
• Synonyms: 4'-HYDROXY-2'-CHLORO ACETOPHENONE;4-HYDROXY-2-CHLOROACETOPHENONE;1-(2-CHLORO-4-HYDROXY-PHENYL)-ETHANONE;1-(2-CHLORO-4-METHOXYPHENYL)ETHANONE;1-(2-chloro-4-Methoxyphenyl)ethan-1-one
• CAS NO: 41068-36-4
• Molecular Formula: C₉H₉ClO₂
• Molecular Weight: 170.59
• Mol File: 41068-36-4.mol
• Article Data: 4

Chemical Properties

• Melting Point: 26–27°C
• Boiling Point: 266°C at 760 mmHg
• Flash Point: 113°C
• Appearance: /
• Density: 1.176g/cm³
• Vapor Pressure: 0.00884mmHg at 25°C
• Refractive Index: 1.521
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2'-CHLORO-4'-HYDROXYACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-CHLORO-4'-HYDROXYACETOPHENONE(41068-36-4)
• EPA Substance Registry System: 2'-CHLORO-4'-HYDROXYACETOPHENONE(41068-36-4)

Safety Data

• Hazardous Substances Data: 41068-36-4(Hazardous Substances Data)

Usage

Uses

1-(2-Chloro-4-hydroxyphenyl)ethanone is used in preparation of aminopyrazine compounds as HPK1 inhibitor and the use thereofof aminopyrazine compounds as HPK1 inhibitor and the use thereof.

Preparation

Obtained by reaction of acetyl chloride with 3-chloroanisole in the presence of aluminium chloride (55%), in carbon disulfide (62%) or in 1,2-dichloroethane (81%).

InChI:InChI=1/C9H9ClO2/c1-6(11)8-4-3-7(12-2)5-9(8)10/h3-5H,1-2H3

Upstream product

• 2845-89-8 1-chloro-3-methoxy-benzene 
• 108-24-7 acetic anhydride 
• 108-43-0 3-monochlorophenol 
• 100-06-1 1-(4-methoxyphenyl)ethanone 

Downstream Products

• 68301-59-7 1-(2-chloro-4-hydroxyphenyl)ethan-1-one 
• 96826-18-5 C₁₈H₂₀Cl₂O₂ 
• 96826-33-4 C₂₀H₂₄Cl₂O₂ 
• 86308-75-0 [2-(2-Chloro-4-methyl-phenoxy)-4-methoxy-phenyl]-acetic acid 
• 89691-25-8 C₁₆H₁₆Cl₂O₂ 
• 89691-43-0 C₁₈H₂₀Cl₂O₂ 
• 89691-44-1 C₁₈H₂₀Cl₂O₂ 
• 1403674-93-0 C₂₅H₂₂ClNO₃ 
• 1403674-92-9 C₂₃H₁₈ClNO₃ 
• 1403674-81-6 5-(2-chloro-4-methoxyphenyl)-2,3-bis(4-methoxyphenyl)-1-propyl-1H-pyrrole 
• 1403674-80-5 5-(2-chloro-4-methoxyphenyl)-2,3-bis(4-methoxyphenyl)-1-methyl-1H-pyrrole 
• 1001441-54-8 4-(2-chloro-4-methoxyphenyl)-1,2-bis(4-methoxyphenyl)-butane-1,4-dione 
• 30095-51-3 2-bromo-1-(2-chloro-4-methoxyphenyl)ethan-1-one 
• 1246383-21-0 5-[2-(2-chloro-4-methoxy-phenyl)-1-hydroxy-1-trifluoromethyl-propyl]-3-methyl-pyridine-2-carbonitrile 

Relevant articles and documents

Catalytic Friedel-Crafts acylation of aromatic ethers using Sml3

10% mol Sml3 catalysed the Friedel-Crafts acylation of aromatic ethers by acyl chlorides in acetonitrile with the yields of 48-82%. Reactions of various substituted aromatic ethers with acyl chloride were studied. The structures of compounds were established by IR and 1H NMR. The main product obtained with anisole is the para-substituted compound with only a trace (3, a pattern repeated with the other aromatic ethers used.

Aqua(sulfato)platinum(II) Complexes with Variable Substituents in the 2-Phenyl Ring. 1. Synthesis and Antitumor and Estrogenic Properties

Erythro- and threo-configurated aqua(sulfato)platinum(II) complexes with variable substituents in the 2-phenyl ring (2-PtSO4 to 9-PtSO4: H, 4-F, 3-OH, 4-OH, 2,6-F2, 2,6-Cl2, 2-F/4-OH, 2-Cl/4-OH) were synthesized and tested for estrogenic and antitumor activities.The ligands were obtained by a three-step reaction.The stilbenes were reacted with a mixture of IN3 and NaN3 to yield the respective 1,2-diazido-1,2-diphenylethanes.The subsequent reduction with LiAlH4 led to the corresponding 1,2-diphenylethylenediamines.The (sulfato)platinum(II) complexes were synthesized by reaction of Ag2SO4 with the diiodo complexes, which had been obtained by coordination of the diamines with K2PtI4.Two complexes, erythro-8-PtSO4 and erythro-9-PtSO4, possess antitumor and estrogenic effects and are therefore of interest for the therapy of breast cancer.