68301-59-7

Basic information

• Product Name: 2'-Chloro-4'-hydroxyacetophenone
• Synonyms: 1-(4-HYDROXY-2-CHLOROPHENYL)ETHANONE;1-(2-CHLORO-4-HYDROXY-PHENYL)-ETHANONE;2'-CHLORO-4'-HYDROXYACETOPHENONE;4'-HYDROXY-2'-CHLORO ACETOPHENONE;4-HYDROXY-2-CHLOROACETOPHENONE;1-(2-Chloro-4-hydroxyphenyl)ethan-1-one;1-(2-Chloro-4-hydroxyphenyl)ethan-1-one, 4-Acetyl-3-chlorophenol
• CAS NO: 68301-59-7
• Molecular Formula: C₈H₇ClO₂
• Molecular Weight: 170.59
• Mol File: 68301-59-7.mol
• Article Data: 1

Chemical Properties

• Melting Point: 110 °C
• Boiling Point: 288 °C at 760 mmHg
• Flash Point: 128 °C
• Appearance: /
• Density: 1.298g/cm³
• Vapor Pressure: 0.00139mmHg at 25°C
• Refractive Index: 1.569
• PKA: 7.21±0.18(Predicted)
• CAS DataBase Reference: 2'-Chloro-4'-hydroxyacetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-Chloro-4'-hydroxyacetophenone(68301-59-7)
• EPA Substance Registry System: 2'-Chloro-4'-hydroxyacetophenone(68301-59-7)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 68301-59-7(Hazardous Substances Data)

Usage

Preparation

Obtained (by-product) by Fries rearrangement of 3-chlorophenyl acetate with aluminium chloride.

InChI:InChI=1/C8H7ClO2/c1-5(10)7-3-2-6(11)4-8(7)9/h2-4,11H,1H3

Upstream product

• 13031-39-5 3-chlorophenyl acetate 
• 41068-36-4 2-chloro-4-methoxyacetophenone 
• 108-43-0 3-monochlorophenol 

Downstream Products

• 30335-75-2 3-(p-Acetyl-m-chlorphenoxy)butanon 
• 30335-98-9 3-Chlor-4-acetyl-phenyl-acetat 
• 816456-26-5 4-[2-(4-acetyl-3-chloro-phenoxy)-ethyl]-piperazine-1-carboxylic acid ethyl ester 
• 30335-99-0 4-Chloro-5-acetyl-2-hydroxyacetophenon 
• 128153-87-7 2-Hydroxy-2-methyl-propionic acid [1-(2-chloro-4-hydroxy-phenyl)-eth-(E)-ylidene]-hydrazide 
• 68301-44-0 4-(2-amino-thiazol-4-yl)-3-chloro-phenol 

Relevant articles and documents

A re-investigation of the Fries rearrangement of 3-chlorophenyl acetate and synthesis of 2-azido-1-(4-(benzyloxy)-2-chlorophenyl)ethanone from 4-bromo-3-chlorophenol

The Fries rearrangement of 3-chlorophenyl acetate provided the expected 4-chloro-2-hydroxy-acetophenone as the major product and 2,4-diacetyl resorcinol and 2-chloro-4-hydroxy-acetophenone as minor products. 4-Benzyloxy-2-chloroacetophenone was prepared by a Heck reaction and then elaborated to 4-benzyloxy-2-chlorophenacyl azide.