4107-00-0

Upstream product

• 110-89-4 piperidine 
• 1871-76-7 diphenylacetic acid chloride 
• 182318-00-9 1-(1H-benzo[d][1,2,3]triazol-1-yl)-2,2-diphenylethan-1-one 
• 618-42-8 1-piperidin-1-yl-ethanone 
• 108-86-1 bromobenzene 
• 4467-90-7 N-hydroxy-2,2-diphenylacetimidoyl chloride 
• 117-34-0 2,2-diphenylacetic acid 
• 58241-10-4 4-nitrophenyl diphenylacetate 
• 81838-54-2 2,2-Diphenyl-1-piperidin-1-yl-ethanone oxime 

Downstream Products

• 101-81-5 Diphenylmethane 
• 1542143-03-2 2,2-diphenyl-1,3-di(piperidin-1-yl)propan-1-one 
• 124140-21-2 diethyl-methyl-(4-oxo-3,3-diphenyl-4-piperidino-butyl)-ammonium; bromide 
• 103156-08-7 1-(2,2-diphenyl-4-piperidino-butyryl)-piperidine 
• 36794-51-1 NSC 45070 

Relevant academic research and scientific papers

A general and practical palladium-catalyzed direct a-arylation of amides with aryl halides

An efficient system for the direct catalytic intermolecular α-arylation of acetamide derivatives with aryl bromides and chlorides is presented. The palladium catalyst is supported by Kwong's indolebased phosphine ligand and provides monoarylated amides in up to 95% yield. Excellent chemoselectivities (>10:1) in the mono- and diarylation with aryl bromides were achieved by careful selection of bases, solvents, and stoichiometry. Under the coupling conditions, the weakly acidic α-protons of amides (pK a up to 35) were reversibly depotonated by lithium tert-butoxide (LiO-t-Bu), sodium tert-butoxide (NaO-t-Bu) or sodium bis(trimethylsilyl)amide [NaN(SiMe3)2].

Antifouling Compounds And Use Thereof

The present invention relates to the use of compounds which have the following general formula (I), wherein R1 and R2 are independently selected from optionally substituted aryl, optionally substituted C1 to C12 /sub

Highly efficient method for the synthesis of carboxamides from carboxylic acids and amines using pyridine-3-sulfonyl chloride (3-PSC)

The use of pyridine-3-sulfonyl chloride (3-PSC) in dehydrating condensation was investigated. This novel reagent was successfully employed as a mild dehydrating reagent for preparing various carboxamides in good to excellent yields from the corresponding carboxylic acids and amines. Copyright

Tetrabenzylpyrophosphate: An efficient catalyst for the synthesis of carboxamides from carboxylic acids and amines

An efficient method for the synthesis of simple and sterically hindered carboxamides from various carboxylic acids and amines using tetrabenzylpyrophosphate (TBPP) as a coupling agent in the presence of 4-(dimethylamino)pyridine (DMAP) is described. The r

Highly efficient method for the synthesis of carboxamides from carboxylic acids and amines using benzenesulfonic anhydride (BSA)

A highly efficient method by using benzenesulfonic anhydride (BSA) in the presence of 4-(dimethylamino)pyridine (DMAP) to synthesize carboxamides from various carboxylic acids and amines including sterically hindered ones is established. This reaction proceeds smoothly to provide the desired product in high yield. Copyright

Ketene-forming elimination reactions from aryl phenylacetates promoted by R2NH in MeCN: Effects of base-solvent and β-phenyl group

Elimination reactions of C6H5C(R)HCO 2C6H3-2-X-4-NO2 [R = H (1), Ph (2), X = H (a), Cl (b), NO2 (c)] promoted by R2NH in MeCN have been studied kinetically. The reactions are second-order and exhibit Broensted β = 0.46-0.89 and |β1g| = 0.37-0.76 and an E2 mechanism is evident. When the base-solvent was changed from R 2NH/R2NH2+-70 mol% MeCN(aq) to R2NH-MeCN, β and |β1g| values remained nearly the same within experimental error. For eliminations from 1 and 2, β and |β1g| values were nearly identical, although the rate was retarded by the β-Ph group. Noteworthy is the relative insensitivity of the ketene-forming transition state to the base-solvent and β-R group variation. Copyright

ANTICANCER CALCIUM CHANNEL BLOCKERS

The present invention is directed to compounds useful as cancer cell inhibitors, compositions containing such compounds and methods for inhibiting proliferation of electrically non-excitable cells.

N-acylbenzotriazoles: Neutral acylating reagents for the preparation of primary, secondary, and tertiary amides

Readily available N-acylbenzotriazoles 2a-q efficiently acylate aqueous ammonia and primary and secondary amines to give primary, secondary, and tertiary amides in good to excellent yields. The wide applicability of the procedure is illustrated by the preparation of (i) α-hydroxyamides from α-hydroxy acids and of (ii) perfluoroalkylated amides.

Ringopening of 3-Substituted 2,3-Epoxynitriles under Acetylating Conditions

The reactivity of 2,3-epoxynitriles 1 towards various acetylating agents was studied.Depending on the reaction conditions, 2,3-diacetoxynitriles 2, 2-acetoxy-3-chloronitriles 5 or enol acetates of α-ketonitriles 3 are formed as main products.