41091-63-8

Upstream product

• 5520-88-7 2-(1-(4-methoxyphenyl)-3-oxo-3-phenylpropyl)cyclohexanone 
• 16717-64-9 1-azidostyrene 
• 5765-29-7 E-2-(4-methoxybenzylidene)cyclohexanone 

Relevant academic research and scientific papers

Pd(II)-Catalyzed Synthesis of Alicyclic[b]-Fused Pyridines via C(sp2)–H Activation of α,β-Unsaturated N-Acetyl Hydrazones with Vinyl Azides

A new synthetic protocol for alicyclic[b]-fused pyridines with complete regioselectivity from α,β-unsaturated N-acetyl hydrazones and vinyl azides via Pd(II)-catalyzed C–H activation/cyclization/aromatization strategy has been described. A series of five-

Three-step synthesis of 2,4-diaryl-5,6,7,8-tetrahydroquinoline derivatives

(Chemical Equation Presented) Addition of cylohexanone to chalcones, obtained from the appropriate acetophenone and benzaldehyde derivatives, under solvent-free conditions gave 1,5-diketones in good yields. Treatment of 1,5-diketones with ammonium acetate in acetic acid afforded directly 2,4-diaryl-5,6,7,8-tetrahydroquinoline derivatives (7a-u) in high yields. The structures of 7a-u were elucidated by 1H NMR, 13C NMR, IR, and elemental analysis.

Certain 5,6,7,8-tetrahydroquinoline-8-thiocarboxamides

The invention relates to novel pyridine derivatives which have a fused 5,6, or 7-membered saturated hydrocarbon ring adjacent to the nitrogen of the pyridine ring, and a group X situated on said hydrocarbon ring and separated by one carbon atom from the pyridine nitrogen atom, said group X is cyano, CONHR3, CSNHR3 or CO2 R5 wherein R3 is selected from hydrogen, lower alkyl and lower aralkyl radicals and R5 is selected from hydrogen, lower alkyl and lower aralkyl radicals which may be substituted by alkyl, alkoxy, halogen, nitro or trifluoromethyl; other substituents may be present. Compounds wherein X is CSNHR3 are anti-ulcer agents and the other compounds are intermediates therefor.

Cyclopenteno[b]pyridine derivatives

The invention relates to novel cyclopenteno[b]pyridine derivatives which have a thioamide group in the 7-position and related tricyclic compounds. The compounds are anti-ulcer agents.

8-Carboxylester, and 8-carbamyl derivitives of 5,6,7,8-tetrahydroquinoline

The invention relates to novel 5,6,7,8-tetrahydroquinoline derivatives which have a group X situated at the 8-position said group X is CONHR3, or CO2 R5 wherein R3 is hydrogen lower alkyl and R5 is hydrogen, lower alkyl or a lower aralkyl radical. The compounds are intermediates for corresponding compounds where X is CSNHR3 and these are anti-ulcer agents.

8-Cyano-5,6,7,8-tetrahydroquinoline derivatives

The invention relates to novel 8-cyano-5,6,7,8-tetrahydroquinoline derivatives which are intermediates for the preparation of corresponding 8-thioamides. Some of the 8-cyano compounds are anti-ulcer agents.

Cyclopenteno[b]pyridine derivatives

The invention relates to novel cyclopenteno[b]pyridine derivatives which have a group X on the 7-position and related tricyclic compounds. X is CONHR3, or CO2 R5 wherein R3 is hydrogen or lower alkyl and R5 is hydrogen or a lower alkyl or lower aralkyl group which may be substituted by alkyl, alkoxy, halogen, nitro or trifluoromethyl; other substituents may be present. The compounds are intermediates for compounds wherein X is CSNHR3 which are anti-ulcer agents.

Pharmaceutical compositions containing 5,6,7,8-tetrahydroquinoline derivatives and related compounds

The invention relates to pharmaceutical compositions containing 5,6,7,8-tetrahydroquinoline-8-thioamides and nitriles and related tricyclic compounds and methods of treating ulcers using said compounds.