41102-25-4

Basic information

• Product Name: 7-Bromo-2,4-dichloro-thieno[3,2-d]pyrimidine
• Synonyms: 7-Bromo-2,4-dichloro-thieno[3,2-d]pyrimidine;7-BroMo-2,4-dichloro-thie...;7-bromothieno[3,2-d]pyrimidin-2,4(1H,3H)-dione
• CAS NO: 41102-25-4
• Molecular Formula: C₆HBrCl₂N₂S
• Molecular Weight: 283.96054
• Mol File: 41102-25-4.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 332.9±42.0 °C(Predicted)
• Appearance: /
• Density: 2.034±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: -2.03±0.40(Predicted)
• CAS DataBase Reference: 7-Bromo-2,4-dichloro-thieno[3,2-d]pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Bromo-2,4-dichloro-thieno[3,2-d]pyrimidine(41102-25-4)
• EPA Substance Registry System: 7-Bromo-2,4-dichloro-thieno[3,2-d]pyrimidine(41102-25-4)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 41102-25-4(Hazardous Substances Data)

Usage

Uses

7-Bromo-2,4-dichlorothieno[3,2-d]pyrimidine can be used for antiproliferative activities.

Upstream product

• 16233-51-5 1H-thieno[3,2-d]pyrimidine-2,4-dione 
• 16233-51-5 2,4-dihydroxythieno[3,2-d]pyrimidine 
• 22288-78-4 Methyl 3-aminothiophene-2-carboxylate 
• 1246223-41-5 7-bromo-2,4-bis(methylthio)thieno[3,2-d]pyrimidine 
• 41102-02-7 7-bromothieno[3,2-d]pyrimidine-2,4(1H,3H)-dione 

Downstream Products

• 1152475-42-7 7-bromo-2-chlorothieno[3,2-d]pyrimidine 
• 1293987-76-4 N-(3-(2-chlorothieno[3,2-d]pyrimidin-7-yl)phenyl)-N-methylmethanesulfonamide 
• 1293987-77-5 2-chloro-N-(3,4,5-trimethoxyphenyl)thieno[3,2-d]pyrimidin-7-amine 
• 1293987-78-6 2-chloro-N-methyl-N-(3,4,5-trimethoxyphenyl)thieno[3,2-d]pyrimidin-7-amine 
• 1293987-54-8 N-(3-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-ylamino)thieno[3,2-d]pyrimidin-7-yl)phenyl)methanesulfonamide hydrochloride 
• 1293987-56-0 3-(2-chlorothieno[3,2-d]pyrimidin-7-yl)benzenamine 
• 1293987-57-1 N-(3-(2-chlorothieno[3,2-d]pyrimidin-7-yl)phenyl)-methanesulfonamide 
• 1293987-05-9 N-(3-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-ylamino)thieno[3,2-d]pyrimidin-7-yl)phenyl)methanesulfonamide 
• 1152475-05-2 7-bromo-N-(3,4,5-trimethoxyphenyl)thieno[3,2-d]pyrimidin-2-amine 

Relevant articles and documents

Designing new isomorphic fluorescent nucleobase analogues: the thieno[3,2-d]pyrimidine core

A convergent approach for a family of fluorescent nucleosides is described. It relies on thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione that serves as a core heterocycle. This condensed pyrimidine is converted into an emissive pyrimidine nucleoside analogue by N-glycosylation and into an emissive purine nucleoside analogue by C-glycosidation at the thiophene's beta position. The design principles of this archetypical system are outlined together with the syntheses and photophysical properties of the resulting nucleosides.

COMPOUNDS AS CD73 INHIBITORS

Provided herein are the compounds that are inhibitors of CD73 and are useful in treating CD73-associated diseases or conditions. Compositions containing the compounds are also provided.

NOVEL TRYPTOPHAN HYDROXYLASE INHIBITOR AND PHARMACEUTICAL COMPOSITION INCLUDING SAME

The present invention relates to a novel tryptophan hydroxylase inhibitor and a pharmaceutical composition including same, wherein the novel tryptophan hydroxylase inhibitor has an excellent inhibitory effect on TPH1, and thus can be usefully used for the prevention or treatment of disorders, such as metabolic disorders, cancer, digestive or cardiovascular system disorders, related to TPH1 activity. In particular, the novel tryptophan hydroxylase inhibitor has an excellent treatment effect on inflammatory bowel disorders, and thus can be usefully used for the treatment of inflammatory bowel disorder.