41113-01-3Relevant academic research and scientific papers
Synthesis method of 3-formylindoles compound
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Paragraph 0038; 0039, (2018/08/04)
The invention relates to a synthesis method of a 3-formylindoles compound. The method comprises the following steps: by taking indoles compounds as raw materials, reacting in DMF under the condition of transitional metallic catalytic system (Pd/Cu), to obtain the 3-formylindoles compound. The synthesis method has the advantages of simple technology, wide application range of reaction substrates, and high yield.
A N - alkyl - 2 - aryl - indole - 3 - aldehyde synthesis method
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Paragraph 0025; 0026, (2017/08/25)
The invention discloses a synthetic method for N-alkyl-2-aryl-indol-3-al and belongs to the technical field of chemical pharmacy and fine chemical preparation. Polysubstituted functionalized indole is an important organic compound. Metal-catalyzed sulfonyl triazole is decomposed into metal carbine, and the metal carbine produces a C-H bond insertion reaction for cyclization to obtain N-alkyl-2-aryl-indol-3-al, that is to say, a 1,2,3-trisubstituted indole structure. The method realizes effective synthesis of high-added-value cyclopropylazacyclo, provides a new technological route for preparing polysubstituted indole derivatives and can be widely applied to the field of chemical pharmacy and fine chemical engineering.
An efficient approach to 1,2,3-trisubstituted indole via rhodium catalyzed carbene Csp3-H bond insertion
Shen, Mei-Hua,Pan, Ying-Peng,Jia, Zhi-Hong,Ren, Xin-Tao,Zhang, Ping,Xu, Hua-Dong
, p. 4851 - 4854 (2015/05/05)
A method for convenient synthesis of N-alkyl-2-aryl-indole-3-carbaldehyde has been described. A variety of highly valuable indolyl aldehydes have been prepared through this method. Electron donating groups on both aromatic rings (anilinyl and benzyl) facilitate the formation of the desired products. A benzylic C-H insertion by rhodium carbene is the key step for this transformation. This journal is
