41117-45-7Relevant academic research and scientific papers
The influence of a β-electron withdrawing substituent in aldol reactions of methylketone boron enolates
Dias, Luiz C.,De Marchi, Anderson A.,Ferreira, Marco A. B.,Aguilar, Andrea M.
, p. 4869 - 4872 (2007)
(Chemical Equation Presented) We wish to describe here that good levels of substrate-based, 1,5-syn-stereocontrol could be achieved in the boron-mediated aldol reactions of β-trichloromethyl methylketones with achiral aldehydes, independent of the nature
1,5-Asymmetric induction in boron-mediated aldol reactions of β-alkoxy methylketones
Dias, Luiz C.,De Marchi, Anderson A.,Ferreira, Marco A. B.,Aguilar, Andrea M.
, p. 6299 - 6311 (2008/12/23)
(Chemical Equation Presented) Good levels of substrate-controlled, 1,5-syn-stereoinduction are obtained in boron-mediated aldol reactions of β-trichloromethyl-β-alkoxy and β-trifluoromethyl-β-alkoxy methylketones with achiral aldehydes, independent of the nature of the β-alkoxy protecting group (TBS or PMB). In the case of boron aldol reactions of β-aryl-β-alkoxy methylketones, the 1,5-anti-adducts were obtained with high levels of diastereoselectivity only with a β-OPMB group.
