411221-85-7

Basic information

• Product Name: 2-(4-iodobenzyl)-isoindoline-1,3-dione
• Synonyms: 2-(4-iodobenzyl)-isoindoline-1,3-dione
• CAS NO: 411221-85-7
• Molecular Weight: 363.154
• Mol File: 411221-85-7.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 2-(4-iodobenzyl)-isoindoline-1,3-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-iodobenzyl)-isoindoline-1,3-dione(411221-85-7)
• EPA Substance Registry System: 2-(4-iodobenzyl)-isoindoline-1,3-dione(411221-85-7)

Safety Data

• Hazardous Substances Data: 411221-85-7(Hazardous Substances Data)

Upstream product

• 16004-15-2 1-bromomethyl-4-iodobenzene 
• 1074-82-4 potassium phtalimide 
• 136918-14-4 phthalimide 
• 18282-51-4 4-iodo-benzyl alcohol 
• 619-58-9 4-iodobenzoic acid 
• 54589-53-6 4-iodobenzyl chloride 
• 227598-41-6 4-[(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)methyl]benzoic acid 

Downstream Products

• 59528-27-7 p-iodobenzylamine hydrochloride 
• 138500-87-5 2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl]isoindoline-1,3-dione 
• 39959-59-6 4-iodobenzyl amine 
• 1192590-76-3 (R)-N-(4-iodo)benzyl 2-N-(tert-butoxycarbonyl)amino-3-methoxypropionamide 
• 1192590-72-9 (R)-N-(4-iodo)benzyl 2-N-(tert-butoxycarbonyl)amino-3-hydroxypropionamide 
• 1197982-73-2 (R)-N-4-(3-methoxypropyl)benzyl 2-acetamido-3-methoxypropionamide 
• 1197982-72-1 (R)-N-4-(3-methoxyprop-1-ynyl)benzyl 2-acetamido-3-methoxypropionamide 
• 1192590-80-9 (R)-N-4'-(iodo)benzyl 2-acetamido-3-methoxypropionamide 
• 951154-49-7 C₁₉H₁₆NO₃I 
• 951154-48-6 C₂₃H₁₈N₂O₃ 
• 951154-46-4 C₂₄H₂₀N₂O₃ 
• 951154-47-5 C₂₃H₁₈N₂O₃ 
• 951154-45-3 C₂₄H₂₀N₂O₃ 

Relevant articles and documents

Palladium-Catalyzed Decarbonylative Iodination of Aryl Carboxylic Acids Enabled by Ligand-Assisted Halide Exchange

We report an efficient and broadly applicable palladium-catalyzed iodination of inexpensive and abundant aryl and vinyl carboxylic acids via in situ activation to the acid chloride and formation of a phosphonium salt. The use of 1-iodobutane as iodide source in combination with a base and a deoxychlorinating reagent gives access to a wide range of aryl and vinyl iodides under Pd/Xantphos catalysis, including complex drug-like scaffolds. Stoichiometric experiments and kinetic analysis suggest a unique mechanism involving C?P reductive elimination to form the Xantphos phosphonium chloride, which subsequently initiates an unusual halogen exchange by outer sphere nucleophilic substitution.

Cu-catalyzed N-3-Arylation of Hydantoins Using Diaryliodonium Salts

A general Cu-catalyzed, regioselective method for the N-3-arylation of hydantoins is described. The protocol utilizes aryl(trimethoxyphenyl)iodonium tosylate as the arylating agent in the presence of triethylamine and a catalytic amount of a simple Cu-salt. The method is compatible with structurally diverse hydantoins and operates well with neutral aryl groups or aryl groups bearing weakly donating/withdrawing elements. It is also applicable for the rapid diversification of pharmaceutically relevant hydantoins.

SUBSTITUTED PYRIDINE DERIVATIVES AS FABI INHIBITORS

The present invention provides substituted pyridine derivatives of formula (I), which may be therapeutically useful as as anti-bacterial agents, more particulalrly FabI inhibitors. Formula(I) in which R1 to R5 and L have the meanings given in the specification, and pharmaceutically acceptable salts thereof that are useful in the treatment and prevention in diseases or disorder, in particular their use in diseases or disorder where there is an advantage anti-bacterial agents, more particularly FabI inhibitors. The present invention also provides methods for synthesizing and administering the FabI inhibitor compounds. The present invention also provides pharmaceutical formulations comprising at least one of the FabI inhibitor compounds together with a pharmaceutically acceptable carrier, diluent or excipient therefor.