41123-14-2

Basic information

• Product Name: 1H-Indole-6-carboxylic acid, 4-(acetyloxy)-, Methyl ester
• Synonyms: 1H-Indole-6-carboxylic acid, 4-(acetyloxy)-, Methyl ester;Methyl 4-acetoxy-1H-indole-6-carboxylate;Methyl 4-acetoxyindole-6-carboxylate, 97%
• CAS NO: 41123-14-2
• Molecular Formula: C12H11NO4
• Molecular Weight: 233.22004
• Mol File: 41123-14-2.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Indole-6-carboxylic acid, 4-(acetyloxy)-, Methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole-6-carboxylic acid, 4-(acetyloxy)-, Methyl ester(41123-14-2)
• EPA Substance Registry System: 1H-Indole-6-carboxylic acid, 4-(acetyloxy)-, Methyl ester(41123-14-2)

Safety Data

• Hazardous Substances Data: 41123-14-2(Hazardous Substances Data)

Usage

General Description

1H-Indole-6-carboxylic acid, 4-(acetyloxy)-, methyl ester, also known as 4-Acetoxy-1-methyl-1H-indole-6-carboxylic acid methyl ester, is a chemical compound with the molecular formula C15H13NO4. It is a methyl ester derivative of a carboxylic acid and is a derivative of the naturally occurring compound, tryptophan. This chemical is commonly used in the synthesis of various pharmaceuticals and is also a key intermediate in the production of indole-based compounds. 1H-Indole-6-carboxylic acid, 4-(acetyloxy)-, methyl ester has a wide range of applications in the pharmaceutical industry and is an important building block in organic chemistry.

InChI:InChI=1S/C12H11NO4/c1-7(14)17-11-6-8(12(15)16-2)5-10-9(11)3-4-13-10/h3-6,13H,1-2H3

Upstream product

• 108-24-7 acetic anhydride 
• 41174-61-2 2-(1H-pyrrol-2-ylmethylene)succinic acid 1-methyl ester 
• 61545-25-3 4-(2-hydroxy-3-tert.-butylaminopropoxy)-6-hydroxymethyl-indole 

Downstream Products

• 77140-48-8 4-hydroxy-1H-indole-6-carboxylic acid methyl ester 
• 41082-79-5 4-methoxy-1H-indole-6-carboxylic acid methyl ester 

Relevant articles and documents

A reinvestigation of 4-hydroxyindole-6-carboxylate synthesis from pyrrole-2-carboxaldehyde: A facile synthesis of indoles and indolizines

Cyclization of the Stobbe product 3 under the literature conditions (acetic anhydride/sodium acetate) affords both the indole 6 and the indolizine 8. The presence of base promotes the formation of indolizine products, and using acetic anhydride/triethylamine leads to indolizine products in good yield. Improved conditions for conversion to indoles 2, 5, and 6 are reported, and inconsistencies in some of the literature structure assignments and characterization data are noted.

Aminopropanol compounds and compositions for the treatment of cardiac and circulatory diseases

New aminopropanol compounds of the formula STR1 wherein R is lower alkyl, cycloalkyl or alkylthioalkyl, R1 is hydrogen or lower alkyl, hydroxyalkyl, pivaloyloxyalkyl, alkoxyalkyl, alkoxycarbonyl, carboxyl or --CONR3 R4, in which R3 and R4 which can be the same or different, represent hydrogen or lower alkyl, and R2 is lower alkyl, hydroxyalkyl, alkoxyalkyl or pivaloyloxyalkyl or, when R is alkylthioalkyl or R1 is pivaloyloxyalkyl, R2 can also be hydrogen and The pharmacologically acceptable salts thereof; are outstandingly effective in the treatment or prophylaxis of cardiac and circulatory diseases.