41123-14-2

Usage

Uses

Used in Pharmaceutical Industry:
1H-Indole-6-carboxylic acid, 4-(acetyloxy)-, methyl ester is used as a key intermediate for the synthesis of various pharmaceuticals. Its unique chemical structure allows it to be a versatile building block in the development of new drugs and therapeutic agents.
Used in Organic Chemistry:
1H-Indole-6-carboxylic acid, 4-(acetyloxy)-, methyl ester is used as an important building block in organic chemistry. Its reactivity and functional groups make it a valuable compound for the synthesis of a wide range of organic compounds, including natural products, pharmaceuticals, and other specialty chemicals.

InChI:InChI=1S/C12H11NO4/c1-7(14)17-11-6-8(12(15)16-2)5-10-9(11)3-4-13-10/h3-6,13H,1-2H3

Upstream product

• 61545-25-3 4-(2-hydroxy-3-tert.-butylaminopropoxy)-6-hydroxymethyl-indole 
• 108-24-7 acetic anhydride 
• 41174-61-2 2-(1H-pyrrol-2-ylmethylene)succinic acid 1-methyl ester 

Downstream Products

• 77140-48-8 4-hydroxy-1H-indole-6-carboxylic acid methyl ester 
• 41082-79-5 4-methoxy-1H-indole-6-carboxylic acid methyl ester 

Relevant academic research and scientific papers

A reinvestigation of 4-hydroxyindole-6-carboxylate synthesis from pyrrole-2-carboxaldehyde: A facile synthesis of indoles and indolizines

Cyclization of the Stobbe product 3 under the literature conditions (acetic anhydride/sodium acetate) affords both the indole 6 and the indolizine 8. The presence of base promotes the formation of indolizine products, and using acetic anhydride/triethylamine leads to indolizine products in good yield. Improved conditions for conversion to indoles 2, 5, and 6 are reported, and inconsistencies in some of the literature structure assignments and characterization data are noted.

Aminopropanol substituted indole compounds and compositions for the treatment of cardiac and circulatory diseases

New aminopropanol compounds of the formula STR1 wherein R is lower alkyl, cycloalkyl or alkylthioalkyl, R1 is hydrogen or lower alkyl, hydroxyalkyl, pivaloyloxyalkyl, alkoxyalkyl, alkoxycarbonyl, carboxyl or --CONR3 R4, in which R3 and R4 which can be the same or different, represent hydrogen or lower alkyl, and R2 is lower alkyl, hydroxyalkyl, alkoxyalkyl or pivaloyloxyalkyl or, when R is alkylthioalkyl or R1 is pivaloyloxyalkyl, R2 can also be hydrogen and the pharmacologically acceptable salts thereof; are outstandingly effective in the treatment or prophylaxis of cardiac and circulatory diseases.

Aminopropanol compounds and compositions for the treatment of cardiac and circulatory diseases

New aminopropanol compounds of the formula STR1 wherein R is lower alkyl, cycloalkyl or alkylthioalkyl, R1 is hydrogen or lower alkyl, hydroxyalkyl, pivaloyloxyalkyl, alkoxyalkyl, alkoxycarbonyl, carboxyl or --CONR3 R4, in which R3 and R4 which can be the same or different, represent hydrogen or lower alkyl, and R2 is lower alkyl, hydroxyalkyl, alkoxyalkyl or pivaloyloxyalkyl or, when R is alkylthioalkyl or R1 is pivaloyloxyalkyl, R2 can also be hydrogen and The pharmacologically acceptable salts thereof; are outstandingly effective in the treatment or prophylaxis of cardiac and circulatory diseases.