77140-48-8Relevant academic research and scientific papers
Flexible synthesis of diverse N-heterocycles from substrates attainable from biomass
Bhusal, Ram Prasad,Sperry, Jonathan
, p. 2453 - 2459 (2016)
A suite of diverse N-heterocycles including dihydroindolone, indole, dihydroindolizinone, 2-pyridone, pyrido[1,2-a]indole, dihydrocarbazolone and carbazole have all been prepared from dimethyl itaconate and pyrrole, two compounds attainable from biomass.
A reinvestigation of 4-hydroxyindole-6-carboxylate synthesis from pyrrole-2-carboxaldehyde: A facile synthesis of indoles and indolizines
Kim, Musong,Vedejs, Edwin
, p. 6945 - 6948 (2007/10/03)
Cyclization of the Stobbe product 3 under the literature conditions (acetic anhydride/sodium acetate) affords both the indole 6 and the indolizine 8. The presence of base promotes the formation of indolizine products, and using acetic anhydride/triethylamine leads to indolizine products in good yield. Improved conditions for conversion to indoles 2, 5, and 6 are reported, and inconsistencies in some of the literature structure assignments and characterization data are noted.
Aminopropanol substituted indole compounds and compositions for the treatment of cardiac and circulatory diseases
-
, (2008/06/13)
New aminopropanol compounds of the formula STR1 wherein R is lower alkyl, cycloalkyl or alkylthioalkyl, R1 is hydrogen or lower alkyl, hydroxyalkyl, pivaloyloxyalkyl, alkoxyalkyl, alkoxycarbonyl, carboxyl or --CONR3 R4, in which R3 and R4 which can be the same or different, represent hydrogen or lower alkyl, and R2 is lower alkyl, hydroxyalkyl, alkoxyalkyl or pivaloyloxyalkyl or, when R is alkylthioalkyl or R1 is pivaloyloxyalkyl, R2 can also be hydrogen and the pharmacologically acceptable salts thereof; are outstandingly effective in the treatment or prophylaxis of cardiac and circulatory diseases.
Aminopropanol compounds and compositions for the treatment of cardiac and circulatory diseases
-
, (2008/06/13)
New aminopropanol compounds of the formula STR1 wherein R is lower alkyl, cycloalkyl or alkylthioalkyl, R1 is hydrogen or lower alkyl, hydroxyalkyl, pivaloyloxyalkyl, alkoxyalkyl, alkoxycarbonyl, carboxyl or --CONR3 R4, in which R3 and R4 which can be the same or different, represent hydrogen or lower alkyl, and R2 is lower alkyl, hydroxyalkyl, alkoxyalkyl or pivaloyloxyalkyl or, when R is alkylthioalkyl or R1 is pivaloyloxyalkyl, R2 can also be hydrogen and The pharmacologically acceptable salts thereof; are outstandingly effective in the treatment or prophylaxis of cardiac and circulatory diseases.
