41123-38-0

Upstream product

• 41003-94-5 diethyl isocyanomethylphosphonate 
• 100-52-7 benzaldehyde 

Downstream Products

• 125760-03-4 ((1R,2R)-1-Amino-2-hydroxy-2-phenyl-ethyl)-phosphonic acid diethyl ester; hydrochloride 
• 125760-01-2 (1R,2R)-(1-amino-2-hydroxy-2-phenylethyl)phosphonic acid 
• 96659-21-1 (1-Amino-2-hydroxy-2-phenyl-ethyl)-phosphonic acid 
• 96659-32-4 diethyl 1-formylamino-2-hydroxy-2-phenylethanephosphonate 
• 52322-67-5 ((E)-1-Formylamino-2-phenyl-vinyl)-phosphonic acid diethyl ester 

Relevant academic research and scientific papers

ENANTIOSELECTIVE SYNTHESIS OF β-HYDROXY-α-AMINOPHOSPHONIC ACID PRECURSORS

The gold(I) catalyzed aldol reaction of diethyl-α-isocyanomethylphosphonate with benzaldehyde gave the oxazoline 3, a β-hydroxy-α-aminophosphonic acid precursor, with high enantio- and diastereoselectivity (98percent trans, 85percent ee) by employing a ch

Asymmetric Synthesis of (1-Aminoalkyl)phosphonic Acids via Asymmetric Aldol Reaction of (Isocyanomethyl)phosphonates Catalyzed by a Chiral Ferrocenylphosphine-Gold(I) Complex

Reaction of aldehydes (R1CHO: R1 = Ph, i-Pr, 3,4-OCH2O-C6H3) with (isocyanomethyl)phosphonates (CNCH2P(O)(OR2)2: R2 = Et, Ph) in the presence of 1 molpercent of a chiral ferrocenylphosphine-gold(I) catalyst gave